@article{Meireles_Araújo_Nascimento_Pinho_Freitas_Almeida_Carvalho_Proença_2021, place={Porto, Portugal}, title={Minimally invasive surfactant therapy in preterm infants: towards less invasive management}, volume={30}, url={https://revistas.rcaap.pt/nascercrescer/article/view/19182}, DOI={10.25753/BirthGrowthMJ.v30.i1.19182}, abstractNote={<p class="p1"><span class="s1"><strong>Introduction:</strong> Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique. </span></p> <p class="p1"><span class="s1"><strong>Material and methods:</strong> Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant.</span></p> <p class="p1"><span class="s1"><strong>Results:</strong> Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (<em>p</em>=0.480), birth weight (<em>p</em>=0.299), fraction of inspired oxygen (FiO<sub>2</sub>) prior to surfactant (<em>p</em>=0.220), oxygen therapy duration (<em>p</em>=0.306), progression to intubation (<em>p</em>=0.712), or length of Neonatal Intensive Care Unit stay (<em>p</em>=0.778). FiO<sub>2</sub> variation before and after surfactant administration was higher in MIST group (14% vs 9%,<em> p</em>=0.078). No significant complications were reported with either technique.</span></p> <p class="p1"><span class="s1"><strong>Conclusions: </strong>MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO<sub>2</sub> requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants. </span></p>}, number={1}, journal={NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL}, author={Meireles, Daniel and Araújo, Luísa Neiva and Nascimento, Marta and Pinho, Liliana and Freitas, Ana Cristina and Almeida, Alexandra and Carvalho, Carmen and Proença, Elisa}, year={2021}, month={Apr.}, pages={18–25} }