Severe hypokalemia in a child with mild gastroenteritis
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v28.i3.15338Keywords:
hypokalemia, electrolyte imbalance, tubulopathy, Gitelman syndromeAbstract
Background: Hypokalemia (serum potassium below 3.5 mmol/L) may be caused by several mechanisms. Severe hypokalemia must be immediately managed, as it can have important cardiac repercussions.
Clinical case: A previously healthy eight-year-old female, with normal growth and normal-to-low blood pressure, was observed due to persistent abdominal pain, anorexia, and fever two days after overcoming a mild gastroenteritis episode. Serum biochemistry revealed severe hypokalemia (1.8 mmol/L), hypomagnesemia, and metabolic alkalosis. The patient was admitted to the Pediatric Intensive Care Unit for correction of electrolyte imbalance, cardiac monitoring, and investigation. Complementary studies included a spot urine ionogram that revealed inappropriate potassium wasting. Ionic correction was achieved by both intravenous and oral supplementation plus spironolactone. Genetic testing was positive for Gitelman syndrome.
Discussion/Conclusion: Suspicion of complex causes should be raised and a comprehensive approach undertaken upon a discrepancy between clinical history and hypokalemia severity.
Downloads
References
2. Somers M, Traum A. Hypokalemia in children. [UpToDate website]. August 22, 2016. (Accessed March 20, 2018) Available at: https://www.uptodate.com/contents/hypokalemia-inchildren.
3. Koudsi L, Nikolova S, Mishra V. Management of a severe case of Gitelman syndrome with poor response to standard treatment. BMJ Case Rep. 2016 Published online [Feb 17 2016]: doi:10.1136/bcr-2015-212375.
4. Bockenhauer D, Zieg J. Electrolyte disorders. Clin Perinatol. 2014; 41:575-90.
5. Knoers NV, Levtchenko EN. Gitelman syndrome. Orphanet J Rare Dis. 2008; 3:22.
6. Blanchard A, Bockenhauer D, Bolignano D, Calò L, Cosyns E, et al. Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2017; 91:24-33.
7. Emmet M, Ellison D. Bartter and Gitelman syndromes. [UpToDate website]. February 7, 2018. (Accessed March 20, 2018). Available at: https://www.uptodate.com/contents/bartter-and-gitelman-syndromes.
8. Colussi G, Bettinelli A, Tedeschi S, De Ferrari M, Syrén M, et al. A thiazide test for the diagnosis of renal tubular hypokalemic disorders. Clin J Am Soc Nephrol. 2007; 2:454-60.
9. Filippatos T, Rizos C, Tzavella E, Elisaf M. Gitelman syndrome: an analysis of the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities. Int Urol Nephrol. 2018; 50:91-6.
10. Huang C, Kuo E. Mechanism of hypokalemia in magnesium deficiency. J Am Soc Nephrol. 2007;18:2649–52.
11. Lin S, Cheng N, Hsu Y, Halperin M. Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium/chloride cotransporter. Am J Kidney Dis. 2004; 43:304-12.
12. Fremont O, Chan J. Understanding Bartter syndrome and Gitelman syndrome. World J Pediatr. 2012; 8:25-30.
13. Cortesi C, Lava SA, Bettinelli A, Tammaro F, Giannini O, Caiata- Zufferey M, et al. Cardiac arrhythmias and rhabdomyolysis in Bartter-Gitelman patients. Pediatr Nephrol. 2010; 25:2005-8.
14. Cruz D, Simon D, Nelson-Williams C, Farhi A, Finberg K, Burleson L, et al. Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension. 2001; 37:1458-64.
15. Bettinelli A, Bianchetti MG, Girardin E, Caringella A, Cecconi M, Appiani AC, et al. Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromes. J Pediatr. 1992; 120:38-43.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in the Birth and Growth Medical Journal are Open Access and meet the requirements of funding agencies and academic institutions. Third-party use of published content is permitted under the terms of the Creative Commons Attribution-NonCommercial (CC BY-NC) license. It is the responsibility of authors to obtain permission for reproducing figures, tables, or other materials from previously published works.
Authors must submit a Conflict of Interest statement and an Authorship Form together with their manuscript. A confirmation email will be sent to the corresponding author upon receipt of the submission. Authors are also permitted to deposit their articles in institutional or personal repositories, provided that the original publication in the Birth and Growth Medical Journal is clearly indicated and the terms of the Creative Commons license are respected.