Pancreatitis and diabetic ketoacidosis in an adolescent treated with sertraline
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v29.i4.17934Keywords:
acute pancreatitis, adolescent, diabetic ketoacidosis, sertraline, thyroiditisAbstract
Acute pancreatitis (AP) is a rare entity in pediatric age. Reports of AP in the context of diabetic ketoacidosis (DKA) have established the role of transient hyperlipemia as a consequent factor.
Pharmacological etiology is responsible for 0.3−1.4% of AP cases, with no case reports of an association with the use of sertraline in the pediatric population to date.
Herein is described the case of a 15-year-old girl with poorly controlled type 1 diabetes, taking sertraline for a depressive disorder, who developed AP associated with DKA.
With this report, the authors intend to emphasize the importance of diagnosing AP in DKA setting. In addition, since the patient had normal serum triglyceride levels and no other risk factors for AP, it is hypothesized that sertraline may have been a triggering event in this context.
Downloads
References
Srinath AI, Lowe ME. Pediatric pancreatitis. Pediatr. Rev. 2013; 34:79–90.
Jones MR, Hall OM, Kaye AM, Kaye AD. Drug-induced acute pancreatitis: A review. Ochsner J. 2015; 15:45–51.
Uc A, Husain SZ. Pancreatitis in Children. Gastroenterology [Internet]. 2019; 156:1969–78. Available from: https://doi.org/10.1053/j.gastro.2018.12.043.
Della Corte C, Faraci S, Majo F, Lucidi V, Fishman DS, Nobili V. Pancreatic disorders in children: New clues on the horizon. Dig. Liver Dis. [Internet]. 2018; 50:886–93. Available from: https://doi.org/10.1016/j.dld.2018.06.016.
Bialo SR. Rare complications of pediatric diabetic ketoacidosis. World J. Diabetes. 2015; 6:167.
Nair S, Yadav D, Pitchumoni CS. Association of diabetic ketoacidosis and acute pancreatitis: Observations in 100 consecutive episodes of DKA. Am. J. Gastroenterol. 2000; 95:2795–800.
Wolfgram PM, MacDonald MJ. Severe hypertriglyceridemia causing acute pancreatitis in a child with new onset type I diabetes mellitus presenting in ketoacidosis. J. Pediatr. Intensive Care. 2013; 2:77–80.
Kim JH, Oh MJ. Acute Pancreatitis Complicated with Diabetic Ketoacidosis in a Young Adult without Hypertriglyceridemia: A Case Report. Korean J. Gastroenterol. 2016; 68:274–8.
Haddad NG, Croffie JM, Eugster EA. Pancreatic enzyme elevations in children with diabetic ketoacidosis. J. Pediatr. 2004; 145:122–4.
Malbergier A, De Oliveira HP. Sertralina e pancreatite aguda: Relato de caso. Rev. Bras. Psiquiatr. 2004; 26:39–40.
Silva MA, Key S, Han E, Malloy MJ. Acute pancreatitis associated with antipsychotic medication: Evaluation of clinical features, treatment, and polypharmacy in a series of cases. J. Clin. Psychopharmacol. 2016; 36:169–72.
Silva M, Sampaio D. Antidepressivos e suicídio nos adolescentes. Acta Med. Port. 2011; 24:603–12.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in the Birth and Growth Medical Journal are Open Access and meet the requirements of funding agencies and academic institutions. Third-party use of published content is permitted under the terms of the Creative Commons Attribution-NonCommercial (CC BY-NC) license. It is the responsibility of authors to obtain permission for reproducing figures, tables, or other materials from previously published works.
Authors must submit a Conflict of Interest statement and an Authorship Form together with their manuscript. A confirmation email will be sent to the corresponding author upon receipt of the submission. Authors are also permitted to deposit their articles in institutional or personal repositories, provided that the original publication in the Birth and Growth Medical Journal is clearly indicated and the terms of the Creative Commons license are respected.