Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction

Authors

  • Raquel Vaz de Castro Serviço de Endocrinologia, Diabetes e Metabolismo Hospital de Santa Maria, CHULN – EPE, Lisboa https://orcid.org/0000-0002-9113-8114
  • Joana Faustino epartment of Pediatrics, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central https://orcid.org/0000-0003-4015-5624
  • Florbela Ferreira Department of Endocrinology, Diabetes and Metabolism, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte
  • Lurdes Sampaio Pediatric Endocrinology Unit, Department of Pediatrics Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte https://orcid.org/0000-0003-3026-9820

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v32.i2.26186

Keywords:

acromegaly, gigantism, cause, clinical feature

Abstract

Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism.
The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction.
GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.

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References

Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, et al. Acromegaly. Nat Rev Dis Primers 2019; 5(1):20. doi: https://doi.org/10.1038/s41472-019-0071-6.

Rostomyan L, Daly AF, Beckers A. Pituitary gigantism: Causes and clinical characteristics. Ann Endocrinol (Paris) 2015;76(6):643-9; doi: https://doi.org/10.1016/j.ando.2015.10.002.

Gadelha MR, Ksuki L, Korbonits M. The genetic background of acromegaly. Pituitary. 2017;20(1):10-21; doi: https://doi.org/10.1007/s11102-017-0789-7.

Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA,Beckers A. High prevalence of pituitary adenomas: across- sectional study in the province of Liege, Belgium. J ClinEndocrinol Metab 2006; 91(12):4769–75. doi: https://doi.org/10.1210/jc.2006-1668.

Kwon O, Song YD, Kim SY, Lee EJ Rare Disease Study Group,Science and Research Committee, Korean Endocrine Society, Nationwide survey of acromegaly in South Korea. ClinEndocrinol (Oxf) 2013; 78(4):577–85. doi: https://doi.org/10.1111/cen.12020.

Holdaway IM, Rajasoorya C, Epidemiology of acromegaly. Pituitary 1999; 2(1):29–41. doi: https://doi.org/10.1023/a:1009965803750.

Nabarro JD. Acromegaly. Clin Endocrinol 1987; 26(4):481–512.

Reid TJ, Post KD, Bruce JN, Nabi Kanibir M, Reyes-Vidal CM, Freda PU. Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains under-recognized and under-diagnosed. Clin Endocrinol 2010; 72(2):203–8. doi: https://doi.org/10.1111/j.1365-2265.2009.03626.x.

Melmed S. Medical progress: Acromegaly . N Engl J Med 2006; 355(24): 2558–73. doi: https://doi.org/10.1056/NEJMra062453.

Molitch ME. Clinical manifestations of acromegaly. Endocrinol Metab Clin North Am 1992; 21(3):597–614.

Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis 2008; 3:17. doi: https://doi.org/10.1186/1750-1172-3-17.

Katznelson L., Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, et al. Acromegaly: An Endocrine Society Clinical Practice Guideline. JCEM 2014; 99(11):3933-51. doi: https://doi.org/10.1210/jc.2014-2700. doi:10.1210/jc.2014-2700.

Salenave S, Boyce AM, Collins MT, Chanson P. Acromegaly and McCune-Albright Syndrome. JCEM 2014; 99(6):1955-69. doi: https://doi.org/10.1210/jc.2013-3826.

Schöfl C, Honegger J, Droste M, Grussendorf M, Finke R, Plöckinger U, et al. Frequency of AIP gene mutations in young patients with acromegaly: a registry-based study. JCEM 2014; 99(12):E2789-E2793. doi: 10.1210/jc.2014-2094. doi: https://doi.org/10.1210/jc.2014-2094.

Beckers A, Rostomyan L, Potorac I, Beckers P, Daly AF. X-LAG: How did they grow so tall? Ann Endocrinol (Paris) 2017; 78(2):131-6. doi: https://doi.org/10.1016/j.ando.2017.04.013.

Sargent J. X-linked acrogigantism – genetic characterization of a newly described paediatric growth disorder. Nat Rev Endocrinol 2015; 11(2):64. doi: https://doi.org/10.1038/nrendo.2014.230.

Gadelha M.R., Kasuki L., Korbonits M. The genetic background of acromegaly. Pituitary. 2017;20:10–21. doi: https://doi.org/10.1007/s11102-017-0789-7.

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Published

2023-09-14

How to Cite

1.
Vaz de Castro R, Faustino J, Ferreira F, Sampaio L. Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction. BGMJ [Internet]. 2023 Sep. 14 [cited 2026 Jan. 11];32(2):103-7. Available from: https://revistas.rcaap.pt/bgmj/article/view/26186

Issue

Vol. 32 No. 2 (2023)

Section

Review Articles

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Copyright (c) 2023 Raquel Vaz de Castro, Joana Faustino, Florbela Ferreira, Lurdes Sampaio

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