Splenic Infarction in a Child with Sickle Cell Trait
Keywords:
pediatrics, sickle cell traitAbstract
Sickle cell trait is a benign condition, though rare complications were reported, often triggered by well-established trigger factors. We report a case of a seven-year-old male child with sickle cell trait, who presented to the Emergency Department with progressively worsening abdominal pain over the previous three days, radiating to the left shoulder, which began during a trip to high altitude mountains. On admission, the child had signs of peritonitis, as diffuse tenderness and general tympany. The ultrasound revealed splenomegaly with a peripheral triangular area, lacking blood flow, suggestive of infarction. He was admitted to the hospital for hydration and pain management, obtaining symptoms control. Further investigation revealed a recent asymptomatic Epstein-Barr virus infection, which may have been an additional precipitating factor alongside the high altitude. This case highlights the relevance of knowing the portability of HbS for achieving a better control of the risk factors that may cause complications in the long run.
Downloads
References
Kotila TR. Sickle Cell Trait: A Benign State? Acta Haematol. 2016;136(3):147-51. doi: https://doi.org/10.1159/000446526. Epub 2016 Jul 16.
Pinto VM, De Franceschi L, Gianesin B, Gigante A, Graziadei G, Lombardini L, et al. Management of the Sickle Cell Trait: An Opinion by Expert Panel Members. J Clin Med. 2023 May 12;12(10):3441. doi: https://doi.org/10.3390/jcm12103441.
Ashorobi D, Ramsey A, Killeen RB, Bhatt R. Sickle Cell Trait. 2024 Feb 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30725815.
Naik RP, Haywood C Jr. Sickle cell trait diagnosis: clinical and social implications. Hematology Am Soc Hematol Educ Program. 2015;2015(1):160-7. doi: https://doi.org/10.1182/asheducation-2015.1.160.
Shephard RJ. Sickle cell trait: what are the costs and benefits of screening? J Sports Med Phys Fitness. 2016 Dec;56(12):1562-1573. Epub 2016 Feb 3. PMID: 26842866.
Jefferson JM, Sims WM, Umeh N, Byeon YJJ, Abdallah KE, Bonham VL, et al. Splenic infarction in sickle cell trait: A comprehensive systematic review of case studies. EJHaem. 2021 Aug;2(3):585-600. doi: https://doi.org/10.1002/jha2.248. Epub 2021 Jul 11.
Thompson AA. Sickle cell trait testing and athletic participation: a solution in search of a problem? Hematology Am Soc Hematol Educ Program. 2013;2013:632-7. doi: https://doi.org/10.1182/asheducation-2013.1.632.
Batista M, Silva C, Gonçalves FMF, Machado M, Freitas S, Silva J, et al. Splenic Infarction: A Rare Complication of Infectious Mononucleosis. Cureus. 2023 Apr 11;15(4):e37414. doi: https://doi.org/10.7759/cureus.37414.
Heo DH, Baek DY, Oh SM, Hwang JH, Lee CS, Hwang JH. Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection. J Med Virol. 2017 Feb;89(2):332-336. doi: https://doi.org/10.1002/jmv.24618. Epub 2016 Jul 6.
Nofal R, Zeinali L, Sawaf H. Splenic infarction induced by epstein-barr virus infection in a patient with sickle cell trait. J Paediatr Child Health. 2019 Feb;55(2):249-251. doi: https://doi.org/10.1111/jpc.14376.
Ma Z, Wang Z, Zhang X, Yu H. Splenic infarction after Epstein-Barr virus infection in a patient with hereditary spherocytosis: a case report and literature review. BMC Surg. 2022 Apr 9;22(1):136. doi: https://doi.org/10.1186/s12893-022-01580-5.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Beatriz Henriques, Rita Ribeiro Martins, Ana Ventura, Teresa Faria

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in the Birth and Growth Medical Journal are Open Access and meet the requirements of funding agencies and academic institutions. Third-party use of published content is permitted under the terms of the Creative Commons Attribution-NonCommercial (CC BY-NC) license. It is the responsibility of authors to obtain permission for reproducing figures, tables, or other materials from previously published works.
Authors must submit a Conflict of Interest statement and an Authorship Form together with their manuscript. A confirmation email will be sent to the corresponding author upon receipt of the submission. Authors are also permitted to deposit their articles in institutional or personal repositories, provided that the original publication in the Birth and Growth Medical Journal is clearly indicated and the terms of the Creative Commons license are respected.