Pollen-food syndrome during pediatric age: a case series

Authors

  • Francisca Cunha Department of Allergy and Clinical Immunology, Unidade Local de Saúde de Coimbra https://orcid.org/0000-0001-9564-7402
  • Filipa Rodrigues dos Santos Department of Allergy and Clinical Immunology, Unidade Local de Saúde de Santo António
  • Leonor Cunha Department of Allergy and Clinical Immunology, Unidade Local de Saúde de Santo António
  • Helena Falcão Department of Allergy and Clinical Immunology, Unidade Local de Saúde de Santo António

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v34.i2.35602

Keywords:

cross-reactivity, food allergy, pediatric age, pollen-food syndrome

Abstract

Introduction: Pollen-food syndrome (PFS) is an immunoglobulin E-mediated reaction, caused by cross-reactivity between pollen and antigens of foods such as those in fruits, vegetables, and/or nuts, in patients with pollinosis.
Aims and Methods: The aim of this study was to present clinical manifestations of PFS, using a case series of six pediatric patients with PFS and pollen allergy referred to our Allergy and Clinical Immunology Department.
Results: The age at diagnosis ranged between 10 and 17 years old, and three of the patients were male. All patients reported experiencing oral allergy syndrome. The main foods reported as triggers were apple, peach, pear, kiwi and banana. The allergic diagnostic workup revealed sensitisation to PR-10 and profilins, the main proteins involved in PFS. Currently, all patients remain asymptomatic after the fresh fruits’ eviction. 
Conclusion: We emphasize the importance of recognition of this entity to provide an adequate management.

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References

Skypala IJ, Hunter H, Krishna MT, Rey-Garcia H, Till SJ, du Toit G, et al. BSACI guideline for the diagnosis and management of pollen food syndrome in the UK. Clin Exp Allergy. 2022 Sep;52(9):1018-1034. doi: https://doi.org/10.1111/cea.14208. Epub 2022 Aug 17. PMID: 35975576.

Olivieri B, Stoenchev KV, Skypala IJ. Anaphylaxis across Europe: are pollen food syndrome and lipid transfer protein allergy so far apart? Curr Opin Allergy Clin Immunol. 2022 Oct 1;22(5):291-297. doi: https://doi.org/10.1097/ACI.0000000000000847. Epub 2022 Aug 4. PMID: 35942860.

Kim M, Ahn Y, Yoo Y, Kim DK, Yang HJ, Park HS, et al; Work Group for Rhinitis, the Korean Academy of Asthma, Allergy and Clinical Immunology. Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndrome. Yonsei Med J. 2019 Oct;60(10):960-968. doi: https://doi.org/10.3349/ymj.2019.60.10.960. PMID: 31538431; PMCID: PMC6753338.

Jeon YH. Pollen-food allergy syndrome in children. Clin Exp Pediatr. 2020 Dec;63(12):463-468. doi: https://doi.org/10.3345/cep.2019.00780. Epub 2020 May 14. PMID: 32403897; PMCID: PMC7738766.

Kim JH. Insights into pediatric pollen food allergy syndrome. Clin Exp Pediatr. 2020 Dec;63(12):483-484. doi: https://doi.org/10.3345/cep.2019.01179. Epub 2020 Jun 1. PMID: 32475107; PMCID: PMC7738767.

Mastrorilli C, Tripodi S, Caffarelli C, Perna S, Di Rienzo-Businco A, Sfika I, et al; Italian Pediatric Allergy Network (I-PAN). Endotypes of pollen-food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification. Allergy. 2016 Aug;71(8):1181-91. doi: https://doi.org/10.1111/all.12888. Epub 2016 May 6. PMID: 26999633.

Mastrorilli C, Cardinale F, Giannetti A, Caffarelli C. Pollen-Food Allergy Syndrome: A not so Rare Disease in Childhood. Medicina (Kaunas). 2019 Sep 26;55(10):641. doi: https://doi.org/10.3390/medicina55100641. PMID: 31561411; PMCID: PMC6843262.

Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC. Food Allergy from Infancy Through Adulthood. J Allergy Clin Immunol Pract. 2020 Jun;8(6):1854-1864. doi: https://doi.org/10.1016/j.jaip.2020.02.010. PMID: 32499034; PMCID: PMC7899184.

Poncet P, Sénéchal H, Charpin D. Update on pollen-food allergy syndrome. Expert Rev Clin Immunol. 2020 Jun;16(6):561-578. doi: https://doi.org/10.1080/1744666X.2020.1774366. PMID: 32691654.

Yagami A, Ebisawa M. New findings, pathophysiology, and antigen analysis in pollen-food allergy syndrome. Curr Opin Allergy Clin Immunol. 2019 Jun;19(3):218-223. doi: https://doi.org/10.1097/ACI.0000000000000533. PMID: 30925494.

Pita JS, Marques ML, Labrador-Horrillo M, Falcão H, Cunha L. Pollen-food syndrome in the adolescent. REVNEC [Internet]. 2019Oct.14 [cited 2024Apr.3];28(3):145-9. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/15730.

Hamada M, Kagawa M, Tanaka I. Evaluation of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome. Asia Pac Allergy. 2021 Oct 19;11(4):e39. doi: https://doi.org/10.5415/apallergy.2021.11.e39. PMID: 34786369; PMCID: PMC8563098.

Bublin M, Radauer C, Knulst A, Wagner S, Scheiner O, Mackie AR, et al. Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like protein. Mol Nutr Food Res. 2008 Oct;52(10):1130-9. doi: https://doi.org/10.1002/mnfr.200700167. PMID: 18655003.

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Published

2025-06-26

How to Cite

1.
Cunha F, Rodrigues dos Santos F, Cunha L, Falcão H. Pollen-food syndrome during pediatric age: a case series . BGMJ [Internet]. 2025 Jun. 26 [cited 2025 Dec. 9];34(2):83-6. Available from: https://revistas.rcaap.pt/bgmj/article/view/35602

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Clinical Case Reports

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