Treatment interruption in small for age term-born children

Authors

  • Alexandre Frascino Endocrinology Unit, Instituto da Criança, Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo https://orcid.org/0000-0002-2741-5201
  • Louise Cominato Endocrinology Unit, Instituto da Criança, Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v29.i1.15101

Keywords:

growth hormone, growth impairment, small-for-gestational-age

Abstract

Small-for-gestational-age children have been associated with up to 20% delayed growth and delayed development, increased childhood morbimortality, and poor quality of life. Prepubertal growth hormone administration results in increased growth and musculoskeletal development. The present case report illustrates the negative impact of growth hormone disruption in a 6-year-old patient, resulting in impaired growth and development. Close clinical and laboratory monitoring is recommended for small-for-gestational-age children receiving growth hormone treatment, and family counselling should be encouraged.

Downloads

Download data is not yet available.

Author Biographies

Alexandre Frascino, Endocrinology Unit, Instituto da Criança, Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo

Alexandre Viana Frascino  Cirurgião Bucomaxilofacial Mestre em Cirurgia Bucomaxilofacial - FOUSP Doutorando em Ciências Médicas - FMUSP Lattes: http://lattes.cnpq.br/7280286564613556 E-mail: alexandre.frascino@usp.br

Louise Cominato, Endocrinology Unit, Instituto da Criança, Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo

Médica assistente da unidade de Endocrinologia do ICR-HC FMUSP.
Coordenadora do ambulatório de Obesidade-FMUSP

 Consultório: (11) 3031-7543/ 98430-9660.
www.endocrinoinfantil.med.br

References

Hofman PL, Regan F, Jackson WE, Jefferies C, Knight DB, Robinson EM, et al. Premature birth and later insulin resistance. N Engl J Med. 2004; 351:2179-86.

Griffin IJ, Lee HC, Profit J, Tancedi DJ. The smallest of the small: short-term outcomes of profoundly growth restricted and profoundly low birth weight preterm infants. J Perinatol. 2015; 35:503-10.

Boguszewski MC, Mericq V, Bergada I, Damiani D, Belgorosky A, Gunczler P, et al. Latin American consensus: children born small for gestational age. BMC Pediatr. 2011; 11:66.

Stalman SE, Solanky N, Ishida M, Aleman-Charlet C, Abu-Amero S, Alders M, et al. Genetic Analyses in Small for Gestational Age Newborns. J Clin Endocrinol Metab. 2018; 103:917-25.

Lee AC, Katz J, Blencowe H, Cousens S, Kozuki N, Vogel JP, et al. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. Lancet Glob Health. 2013; 1:e26-36.

Taha TE, Dadabhai SS, Rahman MH, Sun J, Kumwenda J, Kumwenda NI. Trends in birth weight and gestational age for infants born to HIV-infected, antiretroviral treatment-naive women in Malawi. Pediatr Infect Dis J. 2012; 31:481-6.

Spracklen CN, Ryckman KK, Harland K, Saftlas AF. Effects of smoking and preeclampsia on birth weight for gestational age. J Matern Fetal Neonatal Med. 2015; 28:679-84.

Bogaerts A, Ameye L, Martens E, Devlieger R. Weight loss in obese pregnant women and risk for adverse perinatal outcomes. Obstet Gynecol. 2015; 125:566-75.

Gauthier TW, Guidot DM, Kelleman MS, McCracken CE, Brown LA. Maternal Alcohol Use During Pregnancy and Associated Morbidities in Very Low Birth Weight Newborns. Am J Med Sci. 2016; 352:368-75.

Puertas A, Magan-Fernandez A, Blanc V, Revelles L, O’Valle F, Pozo E, et al. Association of periodontitis with preterm birth and low birth weight: a comprehensive review. J Matern Fetal Neonatal Med. 2018; 31:597-602.

Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric

Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab. 2007; 92:804-10.

Albertsson-Wikland K, Karlberg J. Natural growth in children born SGA with and without catch up growth. Horm Res. 2003; 59:129.

Boonstra V, van Pareren Y, Mulder P, Hokken-Koelega A. Puberty in growth hormone-treated children born small for gestational age (SGA). J Clin Endocrinol Metab. 2003; 88:5753-8.

Methusalemsdottir HF, Egilson S, Guethmundsdottir R, Valdimarsdottir UA, Georgsdottir I. Quality of life of adolescents born with extremely low birth weight. Acta Paediatr. 2013; 102:597-601.

Downloads

Published

2020-03-24

How to Cite

1.
Frascino A, Cominato L. Treatment interruption in small for age term-born children. REVNEC [Internet]. 2020Mar.24 [cited 2025Jan.10];29(1):47-50. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/15101

Issue

Vol. 29 No. 1 (2020)

Section

Case Reports

License

Copyright and Authors' Rights

All articles published in Nascer e Crescer - Birth and Growth Medical Journal are Open Access and comply with the requirements of funding agencies or academic institutions. For use by third parties, Nascer e Crescer - Birth and Growth Medical Journal adheres to the terms of the Creative Commons License "Attribution - Non-Commercial Use (CC-BY-NC)".

It is the author's responsibility to obtain permission to reproduce figures, tables, etc. from other publications.

Authors must submit a Conflict of Interest statement and an Authorship Form with the submission of the article. An e-mail will be sent to the corresponding author confirming receipt of the manuscript.

Authors are permitted to make their articles available in repositories at their home institutions, provided that they always indicate where the articles were published and adhere to the terms of the Creative Commons license.

Similar Articles

You may also start an advanced similarity search for this article.