Cross-allergy between penicillins and cephalosporins: a paradigm shift

Authors

  • Liliana Dias Department of Allergy and Clinical Immunology, Unidade I, Centro Hospitalar Vila Nova Gaia/ Espinho https://orcid.org/0000-0003-2285-4333
  • Cláudia Pedrosa Immunoallergology and Pediatric Pulmonology Unit, Department of Pediatrics, Unidade II, Centro Hospitalar Vila Nova de Gaia/Espinho https://orcid.org/0000-0001-6543-879X

Keywords:

cephalosporin, cross-reactivity, penicillin, side chain

Abstract

Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy.

The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity.

Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.

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Published

2022-04-04

How to Cite

1.
Dias L, Pedrosa C. Cross-allergy between penicillins and cephalosporins: a paradigm shift. REVNEC [Internet]. 2022Apr.4 [cited 2022Dec.5];31(1):31-7. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/21607

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