Infeção tardia por streptococcus agalactiae – um caso de artrite séptica neonatal


  • Ângela Santos S. Ginecologia e Obstetrícia, ULS Alto Minho
  • Beatriz Sousa U. Cuidados Intensivos Neonatais e Pediátricos, S. Pediatria, ULS Alto Minho,
  • Ana Paula Gama S. Ginecologia e Obstetrícia, ULS Alto Minho



Group B streptococcus screening, late-onset group B streptococcus disease, newborn, pregnancy, septic arthritis


Introduction: The incidence of early -onset group B streptococcus (GBS) disease has decreased substantially due to universal antenatal culture screening of pregnant women for GBS colonization at 35 -37 weeks of gestation and the widespread use of intrapartum antibiotic prophylaxis. However, the incidence of late-onset GBS disease has remained constant in the past decade and it is unaffected by maternal intrapartum chemoprophylaxis. Late-onset GBS infection affects infants who had an unremarkable maternal obstetric and early neonatal history. Other sources rather than vertical route, like horizontal transmission from hospital or community, albeit less frequently proved, can justifies late onset GBS disease.

Case report: This case report illustrates a late-onset GBS disease, presenting as neonatal septic arthritis on a caucasian term infant, with unknown route of transmission and highlights the morbidity associated.

Discussion: Additional research pertaining to the transmis- sion of late-onset GBS infections is required to develop effective preventive methods.


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Edwards MS, Nizet V, Baker C. Group B streptococcal infec-

tions. In: Remington JS, Klein JO, CB (eds), et al. Infectious

Diseases of the Fetus and Newborne Infant. 7th Ed. Elsevier

Saunders; 2011:419 -58.

Verani JR, McGee L, Schrag SJ, Division of Bacterial Dise-

ases, National Center for Immunization and Respiratory Di-

seases, Centers for Disease Control and Prevention (CDC).

Prevention on perinatal group B streptococcal disease – revi-

sed guidelines from CDC, 2010. MMWR Recomm Rep 2010;


Campbell JR, Hillier SL, Krohn MA, Ferrieri P, Zaleznik DF,

Baker CJ. Group B streptococcal colonization and serotype-

-specific immunity in pregnant women at delivery. Obstet Gy-

necol 2000; 96:498 -503.

Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH,

Lefkowitz LB, et al. Group B streptococcal disease in the era

of intrapartum antibiotic prophylaxis. N Engl J Med 2000;

:15 -20.

Jordan HT, Farley MM, Craig A, Mohle -Boetani J, Harrison

LH, Petit S, et al. Revisiting the need for vaccine prevention

of late -onset neonatal group B streptococcal disease: a mul-

tistate, population -based analysis. Pediatr Infect Dis J 2008;

:1057 -64.

Phares CR, Lynfield R, Farley MM, Mohel -Boetani J, Harrison

LH, Petit S, et al. Epidemiology of invasive group B strepto-

coccal disease in the United States, 1999 -2005. JAMA 2008;

:2056 -65.

Deshpaud SS, Taral N, Modi N, Singrakhia, M. Changing epi-

demiology of neonatal septic arthritis. J Orthop Surg 2004;

:10 -3.

Morinis J, Shah J, Murthy P, Fulford M. Horizontal transmis-

sion of group B streptococcus in a neonatal intensive care

unit. Paediatr Child Health 2011; 16:e48 -e50.

Cagno CK, Pettit JM, Weiss BD. Prevention of perinatal

group B strptococcal disease: Updated CDC Guideline. Am

Fam Physician 2012; 86:59 -65.

Fernandez M, Rench MA, Albanyan EA, Edwards MS, Baker

CJ. Failure of rifampin to eradicate group B streptococcal co-

lonization in infants. Pediatr Infect Dis J 2001; 20:371 -6.



How to Cite

Santos Ângela, Sousa B, Gama AP. Infeção tardia por streptococcus agalactiae – um caso de artrite séptica neonatal. REVNEC [Internet]. 2016Sep.5 [cited 2023Feb.2];22(4):241-3. Available from:



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