Genotoxic effects of pesticides

Abstract

In addition to all the benefits pesticide usage can bring to crop production and normal daylife, these compounds also present several harmful properties if not correctly used. Their non-specific action increases the possibility of all living organisms (including man) exposed to pesticides undergo severe acute or chronic poisonings. Pesticides are recognized genotoxic compounds that can induce direct damage (damaging directly the bases that constitute the DNA molecule) and indirect damage in DNA (with the production of free radicals). Traditionally, genetic damage was observed by means of chromosomal aberrations. However in the more recent decades new and improved techniques were developed and proved to be useful in understanding the potential of these compounds to induce DNA damage Herein, it will be presented the more recent and relevant data on this matter joining together results of different type of biomarkers: exposure, effect and susceptibility.