Renal Hemosiderosis in Paroxysmal Nocturnal Hemoglobinuria

Abstract

Paroxysmal Nocturnal Hemoglubinuria is a rare acquired myelodysplastic disorder characterized by increased complement-mediated intravascular hemolysis. Deposition of hemosiderin in the proximal tubules of the renal cortex follows intravascular hemolysis. MRI is the best imaging technique to depict hemosiderin deposits, demonstrating the typical signal pattern of renal hemosiderosis. We present a case of renal hemosiderosis in the context of Paroxysmal Nocturnal Hemoglubinuria, discuss its typical findings at MRI, their underlying pathogenesis, and some differential diagnosis.

KeyWords: Paroxysmal Nocturnal Hemoglobinuria; Magnetic Resonance Imaging; Hemosiderosis