Gadolinium Hypersensitivity: Review of Four Cases

Abstract

Immediate hypersensitivity reactions to gadolinium-based contrast agents are uncommon but can be life-threatening. We describe four cases of immediate hypersensitivity reactions to gadobutrol, including anaphylaxis. All patients underwent allergy work-up, with positive skin prick tests to gadobutrol. Two patients also demonstrated cross-reactivity to gadoteric acid. Disodium gadoxetate was tolerated in all cases in magnetic resonance. These findings highlight the importance of individualized allergy work-up to guide safe future imaging.