Preliminary Results of the Implementation of a Patient Blood Management Protocol in the Surgical Correction of Pediatric Scoliosis

Authors

  • Ana Margarida Ferreira Interna do Internato de Formação Específica em Anestesiologia do Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal
  • Sónia Nóbrega Interna do Internato de Formação Específica em Anestesiologia do Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.
  • Marta Alves Gabinete de Investigação, Epidemiologia e Estatística, Centro Hospitalar Universitário de Lisboa Central, Lisboa,Portugal
  • Daniel Virella Gabinete de Investigação, Epidemiologia e Estatística, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal
  • Sara Ramos Interna do Internato de Formação Específica em Anestesiologia do Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal

DOI:

https://doi.org/10.25751/rspa.17186

Keywords:

Blood Loss, Surgical; Blood Transfusion; Child; Clinical Protocols; Erythrocyte Transfusion

Abstract

Background: Pediatric scoliosis surgery, performed to improve quality of life and stop progression of the disease, has significant multifactorial blood loss and consequent consumption of blood products.
A multidisciplinary protocol was implemented to standardize perioperative care and reduce blood product requirements.
Material and Methods: An effectiveness evaluation, with contemporary (protocol “P”; 2016) and historical (pre-protocol “PP”; 2012-2014) cohorts was performed, using a systematic sample of patients aged 2-18 years-old, operated on more than 3 vertebral levels.
Results: Sixty-three patients were recruited: 33 in the PP group and 30 in the P group. Both groups had similar age and weight (median 15 years old and 45 kg), males were more frequent in the group P
(PP 12 vs P 33%). In the P group, the number of patients requiring concentrated erythrocyte unit intraoperative tended to be lower (PP 67% vs P 50%, p = 0.097), more patients received fibrinogen (PP 12%
vs P 33%, p = 0.026) and the amount of fresh frozen plasma transfused tended to be higher (PP 8.6 vs P 13.3 mL/kg, p = 0.091). No statistically significant differences were found on the blood loss. Pre-operatory
haemoglobin tended to be higher in the P group (PP 12.9 vs 13.5 g/ dL, p = 0.079) and the perioperative evolution of haemoglobin levels was different between groups, the haemoglobin level was an average
of 0.45 g/dL higher in the protocol group (p = 0.023).
Conclusion: Multidisciplinary patient blood management protocols may reduce the proportion of patients requiring blood transfusion. 

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References

1. Gambrall MA. Anesthetic implications for surgical correction of scoliosis. AANA J. 2007;75:277-85.
2. Von-Heideken J, Iversen M, Gerdhem P. Rapidly increasing incidence in scoliosis surgery over 14 years in a nationwide sample. Eur Spine J. 2018;27:286-92. doi: 10.1007/s00586-017-5346-6.
3. Mo F, Cunningham ME. Pediatric scoliosis. Curr Rev Musculoskelet Med. 2011;4:175-82. doi: 10.1007/s12178-011-9100-0.
4. Cheng JC, Castelein RM, Chu WC, Danielsson AJ, Dobbs MB, Grivas TB, et al. Adolescent idiopathic scoliosis. Nat Rev Dis Prim. 2015;1:15030. doi: 10.1038/nrdp.2015.30.
5. Ailon T, Sure DR, Smith JS, Shaffrey CI. Surgical considerations for major deformity correction spine surgery. Best Pract Res Clin Anaesthesiol. 2016;30:3-11. doi: 10.1016/j.bpa.2015.11.005.
6. Modi HN, Suh SW, Hong JY, Song SH, Yang JH. Intraoperative blood loss during different stages of scoliosis surgery: A prospective study. Scoliosis. 2010;5:16. doi: 10.1186/1748-7161-5-16.
7. Murphy RF, Mooney JF. Complications following spine fusion for adolescent idiopathic scoliosis. Curr Rev Musculoskelet Med. 2016;9:462-9.
8. Wahlquist S, Wongworawat M, Nelson S. When does intraoperative blood loss occur during pediatric scoliosis correction? Spine Deform. 2017;5:387-91. doi: 10.1016/j.jspd.2017.04.004.
9. Ohrt-Nissen S, Bukhari N, Dragsted C, Gehrchen M, Johansson PI, Dirks J. Blood transfusion in the surgical treatment of adolescent idiopathic scoliosis—a single-center experience of patient blood management in 210 cases. Transfusion. 2017;57:1808-17. doi: 10.1111/trf.14137.
10. Bosch P, Kenkre TS, Londino JA, Cassara A, Yang C, Waters JH. Coagulation profile of patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion. J Bone Joint Surg Am. 2016;88:1-9.
11. Oetgen ME, Litrenta J. Perioperative blood management in pediatric spine surgery. J Am Acad Orthop Surg. 2017;25: 480-8. doi: 10.5435/JAAOS-D-16-00035.
12. Alajmi T, Saeed H, Alfaryan K, Alakeel A, Alfaryan T. Efficacy and safety of tranexamic acid in reducing blood loss in scoliosis surgery: a systematic review and meta-analysis. J Spine Surg. 2017;3:531-40. doi: 10.21037/jss.2017.08.17.
13. McNicol ED, Tzortzopoulou A, Schumann R, Carr DB, Kalra A. Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. Cochrane Database Syst Rev. 2008;3 :CD006883. doi: 10.1002/14651858.CD006883.pub3.
14. Sethna NF, Zurakowski D, Brustowicz RM, Bacsik J, Sullivan LJ, Shapiro F. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology. 2005;102:727-32.
15. Johnson DJ, Johnson CC, Goobie SM, Nami N, Wetzler JA, Sponseller PD, et al. High-dose versus low-dose tranexamic acid to reduce transfusion requirements in pediatric scoliosis surgery. J Pediatr Orthop. 2017;37:e552-7. doi: 0.1097/BPO.0000000000000820.16.
16. Brenn BR, Theroux MC, Dabney KW, Miller F. Clotting parameters and thromboelastography in children with neuromuscular and idiopathic scoliosis undergoing posterior spinal fusion. Spine. 2004;29:E310-4.
17. Ryan KM, O’Brien K, Regan I, O’Byrne JM, Moore D, Kelly PM, et al. The prevalence of abnormal preoperative coagulation tests in pediatric patients undergoing spinal surgery for scoliosis. Spine J. 2015;15:1217-22. doi: 10.1016/j.spinee.2013.07.460.
18. Haas T, Spielmann N, Restin T, Seifert B, Henze G, Obwegeser J, et al. Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery: A prospective randomised controlled trial. Br J Anaesth. 2015;115:234-43. doi: 10.1093/bja/aev136.
19. Borden TC, Bellaire LL, Fletcher ND. Improving perioperative care for adolescent idiopathic scoliosis patients: the impact of a multidisciplinary care approach. J Multidiscip Healthc. 2016; 9:435-45.
20. Gal JS, Curatolo CJ, Zerillo J, Hill B, Lonner B, Cuddihy LA, et al. Anesthetic considerations for a novel anterior surgical approach to pediatric scoliosis correction. Paediatr Anaesth. 2017;7:1028-36. doi: 10.1111/pan.13216. E
21. Guan J, Cole CD, Schmidt MH, Dailey AT. Utility of intraoperative rotational thromboelastometry in thoracolumbar deformity surgery. J Neurosurg Spine. 2017;27:528-33. doi: 10.3171/2017.5.SPINE1788.
22. Edler A, Murray DJ, Forbes RB. Blood loss during posterior spinal fusion surgery in patients with neuromuscular disease: Is there an increased risk? Paediatr Anaesth. 2003;13:818-22.
23. Crescenzi G, Landoni G, Biondi-zoccai G, Pappalardo F, Nuzzi M, Bignam E, et al. Desmopressin reduces transfusion needs after surgery a meta-analysis of randomized clinical trials. Anesthesiology. 2008;109:1063-76. doi: 10.1097/ ALN.0b013e31818db18b.
24. Niescery J, Huhmann N, Dasch B, Bullmann V, Weber TB, Bellgardt M, et al. Effects of liberal vs. conventional volume regimen on pulmonary function in posterior scoliosis surgery. Middle East J Anesthesiol. 2013;22:165-71.
25. Grant JA, Howard J, Luntley J, Harder J, Aleissa S, Parsons D. Perioperative blood transfusion requirements in pediatric scoliosis surgery: the
efficacy of tranexamic acid. J Pediatr Orthop. 2009;29:300-4. doi: 10.1097/
BPO.0b013e31819a85de.

Published

2019-05-28

How to Cite

Ferreira, A. M., Nóbrega, S., Alves, M., Virella, D., & Ramos, S. (2019). Preliminary Results of the Implementation of a Patient Blood Management Protocol in the Surgical Correction of Pediatric Scoliosis. Journal of the Portuguese Society of Anesthesiology, 28(2), 90–95. https://doi.org/10.25751/rspa.17186