Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study
DOI:
https://doi.org/10.25751/rspa.26144Keywords:
Postoperative; Nausea and vomiting; Prophylaxis; Pregabalin; OndansetronAbstract
Introduction:
Pregabalin is an antiepileptic drug with antiemetic properties. We evaluated prophylactic oral pregabalin as compared with ondansetron for postoperative nausea and vomiting (PONV) in patients undergoing mastoid surgery in a randomized double-blind study.
Material and Methods:
Two hundrd patients of ASA physical status I and II, scheduled to undergo mastoid surgery, were randomly assigned into two groups to receive 150 mg pregabalin or 8 mg ondansetron one hour before surgery. Standard anaesthesia technique was used in all patients. Episodes of PONV were recorded during the first 24 h for two time periods: 0–2 and 2–24 h. Data regarding adverse effects, such as dizziness, headache and drowsiness, were also collected.
Categorical variables were expressed as frequency (%) and chi-square test was applied to test the significance of association between groups and variables. Continuous variables were expressed as Mean with 95% confidence intervals. T-test was performed to compare the mean of variables between two groups. Kaplan-Meier survival analysis was performed for comparing mean or median time of events. Log-rank test was used to test the median survival time. Kolmogorov-Smirnov test was used for testing the equality of the distribution function of sedative score at each time point.
Results:
Pregabalin prophylaxis in patients undergoing mastoid surgery delays the onset and decreases the episodes of vomiting within 2-hours of surgery as compared to ondansetron 8mg. It also reduces the incidence of nausea in the postoperative period, albeit at the cost of higher incidence of sedation.
Conclusions: Pregabalin effectively suppresses PONV in mastoid surgery.
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Copyright (c) 2022 Uzma Raihan, Prakash Dubey
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