Multimodal anaesthesia for mitral valve replacement in a patient with a pheochromocytoma
DOI:
https://doi.org/10.25751/rspa.33322Keywords:
Cardiothoracic surgery, Pheochromocytoma, Cardiac anesthesiaAbstract
Pheochromocytomas are rare neuroendocrine tumours that produce and store catecholamines. Intraoperatively, the release of excessive amounts of catecholamines can produce life-threatening cardiovascular complications.
This is a case report of a woman in her 60s recently diagnosed with a pheochromocytoma in need of a mitral valve replacement due to anterior leaflet prolapse and ruptured chord.
Due to the possibility of worsening mitral regurgitation and cardiovascular collapse after a hypertensive crisis during adrenalectomy we prioritised the cardiac surgery.
Intraoperatively, we performed a multimodal total intravenous anaesthesia with propofol and low-dose infusions of remifentanil and dexmedetomidine. Hemodynamic stability was maintained throughout the procedure and two months later the patient underwent a laparoscopic adrenalectomy uneventfully.
Although pheochromocytoma removal is usually a priority surgery, when facing serious cardiovascular pathology, such as severe mitral regurgitation, it may be a better option to prioritise the cardiac surgery over the pheochromocytoma removal.
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Naranjo J, Dodd S, Martin YN. Perioperative Management of Pheochromocytoma. J Cardiothorac Vasc Anesth. 2017 Aug;31(4):1427-1439. doi: 10.1053/j.jvca.2017.02.023. Epub 2017 Feb 4. PMID: 28392094.
Gupta A, Garg R, Gupta N. Update in perioperative anesthetic management of pheochromocytoma. World J Anesthesiol 2015; 4(3): 83-90. doi: 10.5313/wja.v4.i3.83.
Balabaud-Pichon V, Bopp P, Levy F, et al. Excision of adrenal pheochromocytoma and coronary artery bypass graft surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2002 Jun;16(3):344-6. doi: 10.1053/jcan.2002.124145.
Seah PW, Costa R, Wolfenden H. Combined coronary artery bypass grafting and excision of adrenal pheochromocytoma. J Thorac Cardiovasc Surg. 1995 Aug;110(2):559-60. doi: 10.1016/S0022-5223(95)70260-1.
Baillargeon JP, Pek B, Teijeira J, et al. Combined surgery for coronary artery disease and pheochromocytoma. Can J Anaesth. 2000 Jul;47(7):647-52. doi: 10.1007/BF03018998.
Feinstein I, Lee T, Khan S, et al. A case report of an open aortic valve replacement followed by open adrenalectomy in a patient with symptomatic pheochromocytoma and critical aortic stenosis. J Cardiothorac Surg. 2021 Sep 28;16(1):282. doi: 10.1186/s13019-021-01665-x.
To AC, Frost C, Grey AB, et al. Combined coronary artery bypass grafting and phaeochromocytoma excision. Anaesthesia. 2007 Jul;62(7):728-33. doi: 10.1111/j.1365-2044.2007.05071.x.
Lenders JWM, Kerstens MN, Amar L, et al. Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension. J Hypertens. 2020 Aug;38(8):1443-1456. doi: 10.1097/HJH.0000000000002438.
Connor, D. and Boumphrey, S. Perioperative care of Phaeochromocytoma. BJA Education. 2016 May;16(5), pp. 153–158. doi:10.1093/bjaed/mkv033.
Shanker A, Abel JH, Narayanan S, et al. Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries: The Pathfinder Feasibility Trial. Front Med (Lausanne). 2021 Oct 14;8:719512. doi: 10.3389/fmed.2021.719512.
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