Positive hepatitis B surface antigen after vaccination in a newborn

Authors

  • Mariana Martins Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
  • Ivete Afonso Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
  • Alexandrina Portela Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
  • Rui Almeida Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v27.i2.10403

Keywords:

Hepatitis B surface antigen, Hepatitis B virus, Vaccination

Abstract

Hepatitis B vaccination is included in the Portuguese national health plan. Vaccine-induced hepatitis B surface antigen positivity is described in literature, leading to diagnostic errors if the serological test is prematurely performed after vaccination. We report the case of a false positive transient B surface antigenemia in a premature baby born from a hepatitis B vaccinated mother. Caution is required when seropositivity is found after administration of hepatitis B vaccine in order to avoid anxiety in parents and unnecessary exams.

Downloads

Download data is not yet available.

References

American Academy of Pediatrics, Committee on Infectious Diseases. (2003). Hepatitis B. In LK Pickering (Ed.), Red Book: Report of the Committee on Infectious Diseases (26th ed., pp. 318-336).

Direção geral de saúde. Norma número 040/2011 de 21 de dezembro. Programa nacional de vacinação 2012.

Fleischer L, Syed S. Hepatitis B Surface Antigenemia in a Neonate Following Vaccination With Pediarix. Clinical Pediatrics, 2009;48(3):311-312.

Mantadakis E, Thomaidis S, Efraimidou EN, Ramatani A, Chatzimichael A. Transient hepatitis B surface antigen circulation after Infanrix-Hexa®: a case report and review of the literature. European Journal of Pediatrics, 2010;169:1139-1141.

Rysgaard CD, Morris CS, Drees D, Bebber T, Davis SR, Kulhavy J, et al. Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem. BMC Clinical Pathology 2012;12:15.

Otag F. False positive HBsAg result in blood donors due to administration of three different recombinant DNA Hepatitis B vaccines. Vaccine 21, 2003(25-26):3734-3737.

Lunn ER, Hoggarth BJ, Cook WJ. Prolonged Hepatitis B Surface Antigenemia After Vaccination. Pediatrics 2000;105(6).

Downloads

Published

2018-07-13

How to Cite

1.
Martins M, Afonso I, Portela A, Almeida R. Positive hepatitis B surface antigen after vaccination in a newborn. REVNEC [Internet]. 2018Jul.13 [cited 2023Mar.20];27(2):105-7. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/10403

Issue

Vol. 27 No. 2 (2018)

Section

Case Reports

License

Copyright and access

This journal offers immediate free access to its content, following the principle that providing free scientific knowledge to the public provides greater global democratization of knowledge.
The works are licensed under a Creative Commons Attribution Non-commercial 4.0 International license.
Nascer e Crescer – Birth and Growth Medical Journal do not charge any submission or processing fee to the articles submitted.

Most read articles by the same author(s)