Positive hepatitis B surface antigen after vaccination in a newborn

  • Mariana Martins Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
  • Ivete Afonso Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
  • Alexandrina Portela Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
  • Rui Almeida Department of Pediatrics, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos
Keywords: Hepatitis B surface antigen, Hepatitis B virus, Vaccination

Abstract

Hepatitis B vaccination is included in the Portuguese national health plan. Vaccine-induced hepatitis B surface antigen positivity is described in literature, leading to diagnostic errors if the serological test is prematurely performed after vaccination. We report the case of a false positive transient B surface antigenemia in a premature baby born from a hepatitis B vaccinated mother. Caution is required when seropositivity is found after administration of hepatitis B vaccine in order to avoid anxiety in parents and unnecessary exams.

References

American Academy of Pediatrics, Committee on Infectious Diseases. (2003). Hepatitis B. In LK Pickering (Ed.), Red Book: Report of the Committee on Infectious Diseases (26th ed., pp. 318-336).

Direção geral de saúde. Norma número 040/2011 de 21 de dezembro. Programa nacional de vacinação 2012.

Fleischer L, Syed S. Hepatitis B Surface Antigenemia in a Neonate Following Vaccination With Pediarix. Clinical Pediatrics, 2009;48(3):311-312.

Mantadakis E, Thomaidis S, Efraimidou EN, Ramatani A, Chatzimichael A. Transient hepatitis B surface antigen circulation after Infanrix-Hexa®: a case report and review of the literature. European Journal of Pediatrics, 2010;169:1139-1141.

Rysgaard CD, Morris CS, Drees D, Bebber T, Davis SR, Kulhavy J, et al. Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem. BMC Clinical Pathology 2012;12:15.

Otag F. False positive HBsAg result in blood donors due to administration of three different recombinant DNA Hepatitis B vaccines. Vaccine 21, 2003(25-26):3734-3737.

Lunn ER, Hoggarth BJ, Cook WJ. Prolonged Hepatitis B Surface Antigenemia After Vaccination. Pediatrics 2000;105(6).

Published
2018-07-13
How to Cite
Martins, M., Afonso, I., Portela, A., & Almeida, R. (2018). Positive hepatitis B surface antigen after vaccination in a newborn. NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL, 27(2), 105-107. https://doi.org/10.25753/BirthGrowthMJ.v27.i2.10403
Section
Case Reports

Most read articles by the same author(s)