• Teresa M Guimarães Pediatric Endocrinology Unit, CH Porto
  • Mónica Tavares Pediatric Endocrinology Unit, CH Porto
  • Maria João Oliveira Pediatric Endocrinology Unit, CH Porto
  • Luciana Sousa Radiology Department, CH Porto
  • Teresa Borges Pediatric Endocrinology Unit, CH Porto



Ovarian cyst, precocious puberty, precocious pseudopuberty, uterine hemorrhage, GnRh analog


Introduction: Ovarian cysts are rare in prepubertal girls. Autonomous ovarian cysts represent 5% of cases and can cause isosexual precocious pseudopuberty.

Case Report: A five years old girl was observed because of vaginal bleeding. Personal and family history was unremarkable. Physical examination confi rmed uterine haemorrhage and bilateral breast development. Pelvic ultrasound examination demonstrated a 30mm right ovarian cyst. Laboratory fi ndings, including thyroid function, were normal, excepting elevated oestrogen levels. GnRH stimulation test showed prepubertal response. There was no advanced bone age nor accelerated height velocity. She was regularly monitored at paediatric endocrinology consultation, without recurrent menorrhagia, there was regression of thelarche, associated with involution of the ovarian cyst.

Discussion/Conclusion: Most autonomous ovarian cysts regress spontaneously with regression of pubertal signs, as in the present case. Therapy with a GnRH agonist may become necessary in the case of transformation from precocious pseudopuberty to central precocious puberty after recurrences of the ovarian cysts or when there is significant loss of height potential.


Millar DM, Blake JM, Stringer DA, Hara H, Babiak C. Prepubertal

Ovarian Cyst Formation: 5 Years’ Experience. Obstet

Gynecol 1993; 81:434 -8.

Pienkowski C, Baunin C, Gayrard M, Lemasson F, Vayasse

P, Tauber M. Ovarian Cysts in Prepubertal Girls. In: Sultan C

(ed) Pediatric and Adolescent Gynecology. Evidence -Based

Clinical Practice. Basel: Karger; 2004. P. 66 -76.

Laufer MR. Ovarian cysts and neoplasms in infants, children

and adolescents. UptoDate 2010. Disponível em: http://www. -cysts -and -neoplasms -in-

-infants -children -and -adolescents

Rodriguez -Macias KA, Thibaud E, Houang M, Dufl os C, Beldjord

C, Rappaport R. Follow up of precocious pseudopuberty

associated with isolated ovarian follicular cysts. Arch Dis

Child 1999, 81:53 -6.

Warner BW, Kuhn JC, Barr LL. Conservative management

of large ovarian cysts in children: the value of serial pelvic

ultrasonography. Surgery 1992; 112:749 -55.

Thind CR, Carty HM, Pilling DW. The role of ultrasound in

the management of ovarian masses in children. Clin Radiol

; 40:180 -2.

Matarazzo P, Lala R, Andreo M, Einaudi S, Viora E, Buzi F,

et al. McCune -Albright syndrome: persistence of autonomous

ovarian hyperfunction during adolescence and early adult

age. J Pediatr Endocrinol Metab 2006; 19:607 -17.

Partsch CJ, Kreller -Laugwitz G, Sippell WG. Transitorische

Pseudopubertas praecox aufgrund autonomer Ovarialzysten.

Monatsschr Kinderheilkd 1989; 137:235 -8.

Strickland JL. Ovarian cysts in neonates, children and adolescents.

Curr Opin Obstet Gynecol 2002; 14:459 -65.

Kappy MS, Ganong CS. Advances in the treatment of precocious

puberty. Adv Pediatr 1994; 41:223 -61.



How to Cite

Guimarães, T. M., Tavares, M., Oliveira, M. J., Sousa, L., & Borges, T. (2017). PRECOCIOUS PUBERTY DUE TO OVARIAN CYST – CASE REPORT. NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL, 22(2), 92–94.



Case Reports

Most read articles by the same author(s)