POLYCYSTIC OVARY SYNDROME IN ADOLESCENCE
Introduction:Polycystic Ovary Syndrome is recognized as the most common endocrine disorder of reproductive-age women. The syndrome often presents during adolescence, but the diagnosis in this age group is complicated by the overlap between features of the syndrome and physiologic findings observed during the normal progression of puberty.
Objective:To review the diagnosis and treatment of Polycystic Ovary Syndrome in adolescence.
Development:There are no consensual diagnostic criteria or treatment guidelines for Polycystic Ovary Syndrome in pediatric population. Many features of the syndrome, including acne, menstrual irregularities and hyperinsulinemia, are common in normal puberty. Most authors recommend a diagnosis based on clinical and/or biochemical evidence of hyperandrogenism with ovarian dysfunction, not explained by other causes. Measurement of free testosterone level is the more sensitive and reliable method for establishing the existence of androgen excess. Ultrasonographic visualization of polycystic ovary doesn’t set the diagnosis, because it’s a frequent finding in healthy adolescents. Lifestyle changes and treatment of hirsutism and menstrual irregularities are essential hallmarks in the therapeutic approach of Polycystic Ovary Syndrome in adolescents.
Conclusion: Identification of adolescents at risk for Polycystic Ovary Syndrome is critical, not only for an appropriate therapeutic approach, but also to prevent co-morbidities associated with the syndrome, including obesity, insulin resistance, dyslipidemia and infertility.
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