One silence, different clinical pictures

Landau Kleffner Syndrome: Differential diagnosis

Authors

  • Patricia Magalhães Department of Child and Adolescent Psychiatry, Centro Materno-Infantil do Norte, Centro Hospitalar e Universitário do Porto
  • Mafalda Marques Department of Child and Adolescent Psychiatry, Hospital Pediátrico de Coimbra, Centro Hospitalar e Universitário de Coimbra, Hospital Pediátrico de Coimbra, Centro Hospitalar e Universitário de Coimbra
  • Vânia Martins Department of Child and Adolescent Psychiatry, Centro Materno-Infantil do Norte, Centro Hospitalar e Universitário do Porto
  • Rui Chorão Neuropediatrics Unit, Centro Materno-Infantil do Norte, Centro Hospitalar e Universitário do Porto
  • Sónia Figueiroa Neuropediatrics Unit, Centro Materno-Infantil do Norte, Centro Hospitalar e Universitário do Porto

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v31.i2.20611

Keywords:

aphasia, auditory verbal agnosia, differential diagnosis, epileptic encephalopathy, Landau Kleffner syndrome

Abstract

Landau Kleffner syndrome (LKS) is a rare epileptic encephalopathy characterized by acquired receptive and expressive aphasia and epileptic seizures in a previously normal child. The diagnosis can be challenging and commonly mistaken with other clinical pictures, namely emotional conditions, mainly when identifiable triggers are present in the patient’s history.
The authors present the case of a four-year-old Portuguese girl who moved to China with her parents and sister and started presenting regression of expressive and comprehensive language and behavioral problems around the same time that they changed country. The aim of this study is to document a case of LKS and briefly review the subject, highlighting the complexity of the differential diagnosis.

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References

Baumer F, Cardon A, Porter B. Language Dysfunction in Pediatric Epilepsy. Journal of Pediatrics. 2018; 194: 13-21.

Tuft M, Arva M, Bjørnvold M, Wilson JA, Nakken KO. Landau-Kleffner syndrome. Tidsskr Nor Laegeforen. 2015; 135(22):2061-4.

Malvestio C. Landau-Kleffner Syndrome (LKS): A Rare Childhood Neurological Syndrome. American Journal of Electroneurodiagnostic Technology. 2010; 50:122-32.

Camfield P, Camfield C. Regression in children with epilepsy. Neuroscience and Biobehavioral Reviews. 2019; 96:210-8.

Caraballo R, Cejas N, Chamorro N, Kaltenmeier M, Fortini S, Soprano A. Landau–Kleffner syndrome: A study of 29 patients. Seizure. 2014; 23(2):98-104.

Kaga M, Inagaki M, Ohta R. Epidemiological study of Landau–Kleffner syndrome (LKS) in Japan. Brain & Development. 2014; 36(4):284-6.

Conroy J, Mcgettigan PA, McCreary D, Shah N, Collins K, Parry-Fielder B et al. Towards the identification of a genetic basis for Landau‐Kleffner syndrome. Epilepsia, Official Journal of the International League Against Epilepsy. 2014; 55(6):858-65.

Appendino JP, Appendino JI. Encefalopatías epilépticas determinadas genéticamente. Medicina (Buenos Aires). 2019; 79 (3): 42-7.

Arts WF, Aarsen FL, Boer MS, Catsman-Berrevoets CE. Landau-Kleffner syndrome and CSWS syndrome: treatment with intravenous immunoglobulins. Epilepsia. 2009; 50 (7): 55-58.

World Health Organization. (2018). International classification of diseases for mortality and morbidity statistics (11th Revision). Available at: https://icd.who.int/browse11/l-m/en.

Hua A, Major N. Selective Mutism. Current Opinion Pediatric. 2016; 28(1):114-20.

Levisohn P. Electroencephalography findings in autism: similarities and differences from Landau-Kleffner Syndrome. Seminars Pediatric Neurology. 2004; 11(3):218-24.

Boer M. Guidelines for EEG in encephalopathy related to ESES/CSWS in children. Epilepsia. 2009; 50 (7): 13-7.

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Published

2022-06-30

How to Cite

1.
Magalhães P, Marques M, Martins V, Chorão R, Figueiroa S. One silence, different clinical pictures: Landau Kleffner Syndrome: Differential diagnosis. REVNEC [Internet]. 2022Jun.30 [cited 2024May6];31(2):148-52. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/20611

Issue

Vol. 31 No. 2 (2022)

Section

Case Reports

License

Copyright (c) 2022 Patricia Magalhães, Mafalda Marques, Vânia Martins, Rui Chorão, Sónia Figueiroa

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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