When a disease doesn´t come alone: A case report of polyglandular autoimmune syndrome type 2

Authors

  • Mariana Vieira Silva Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões https://orcid.org/0000-0002-4908-209X
  • João Nuno Sousa Marques Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões https://orcid.org/0000-0002-2845-3357
  • Inês Coutinho Oliveira de Lima Madanelo Unidade de Cuidados de Saúde Personalizados Vila Nova de Paiva ACeS Dão Lafõe https://orcid.org/0000-0001-5109-8405
  • Carla Sofia Morgado Pinto Reis Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões
  • Joana Filipa Marques Pimenta Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões
  • Joaquina Conceição Fernandes Antunes Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões https://orcid.org/0000-0002-7855-5933
  • Elisabete Maria Costa e Silva Santos Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões https://orcid.org/0000-0002-4042-9819
  • Cristina Celeste Fernandes de Faria Department of Pediatrics, Unidade Local de Saúde de Viseu Dão-Lafões https://orcid.org/0000-0002-0902-9964

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v33.i3.28361

Keywords:

Addison´s disease, autoimmune polyglandular syndrome type 2, Hashimoto’s thyroiditis

Abstract

Autoimmune polyglandular syndromes (PAS) are a complex and heterogeneous group of diseases characterized by the combination of two or more endocrine or non-endocrine organ dysfunctions.
Herein is presented the case of a 16-year-old female with a history of asthenia, prostration, and weight loss who was diagnosed with hypothyroidism and iron deficiency anemia. Two weeks after starting therapy with levothyroxine and iron, she developed an adrenal crisis with nausea and vomiting. Low cortisol, elevated adrenocorticotropic hormone, and positive antiadrenal and antithyroid peroxidase antibodies confirmed the diagnosis of autoimmune polyglandular syndrome type 2 (PAS-2). Symptoms resolved with hydrocortisone, fludrocortisone, and levothyroxine.
PAS-2 is a rare but potentially serious disorder. A high clinical suspicion is required, as most symptoms are nonspecific. Early diagnosis may prevent life-threatening complications.

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Published

2024-10-22

How to Cite

1.
Silva MV, Sousa Marques JN, Coutinho Oliveira de Lima Madanelo I, Morgado Pinto Reis CS, Marques Pimenta JF, Fernandes Antunes JC, Costa e Silva Santos EM, Fernandes de Faria CC. When a disease doesn´t come alone: A case report of polyglandular autoimmune syndrome type 2. REVNEC [Internet]. 2024Oct.22 [cited 2025Mar.4];33(3):202-6. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/28361

Issue

Vol. 33 No. 3 (2024)

Section

Case Reports

License

Copyright (c) 2024 Mariana Vieira Silva, João Nuno Sousa Marques, Inês Coutinho Oliveira de Lima Madanelo, Carla Sofia Morgado Pinto Reis, Joana Filipa Marques Pimenta, Joaquina Conceição Fernandes Antunes, Elisabete Maria Costa e Silva Santos, Cristina Celeste Fernandes de Faria

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