Drug hypersensitivity in pre-school children
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v25.i1.8821Keywords:
Drug Allergy, Drug Allergy diagnosis, pediatrics, drug provocation testsAbstract
Introduction: Drug hypersensitivity reactions (DHRs) are reproducible adverse effects of drugs, taken at a normal therapeutic dose, which clinically resemble allergy. The reported prevalence in children is up to 10%. The investigation of these reactions may require skin testing, dosing of drug specific immunoglobulin E (IgE) and drug provocation tests.
Objective: The aim of this study is to report the results of DHRs workup in pre-school children seen at the drug allergy clinic from January 2007 to December 2012.
Material and Methods: This study included 189 children (61% male), which first suspected drug hypersensitivity reaction occurred before the age of six years that were evaluated for DH in the referred time period.
Results: Culprit drugs were beta-lactams in 82% of the cases and NSAIDs in 10%. The clinical history was suggestive of an immediate-type reaction in 18% of the cases and the most prevalent manifestations were cutaneous (90%). The workup was completed in 118 patients (62%). Drug Hypersensitivity was confirmed in six patients (5%) and excluded in 95% of the patients who completed the workup, without any serious complications.
Conclusion: These results show the applicability and value of this diagnostic approach in pre-school children.
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