Evaluation of the Systemic Pro-Inflammatory Response Associated with Diabetic Retinopathy as a Limiting Factor on the Efficacy of Intravitreal Treatment for Diabetic Macular Edema

Authors

  • Pedro Silva Brito Opthalmology Department, Hospital de Braga, Braga, Portugal; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, Portugal
  • Jorge Correia Pinto Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, Portugal; ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
  • Rufino Silva Department of Ophthalmology. Centro Hospitalar e Universitario de Coimbra (CHUC), Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research. Faculty of Medicine.University of Coimbra (iCBR- FMUC, Coimbra, Portugal); Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal

DOI:

https://doi.org/10.48560/rspo.24503

Keywords:

Diabetic Retinopathy, Macular Edema, Vascular Endothelial Growth Factor A

Abstract

        

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References

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Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology. 2010; 117:1078-86;1072. doi: 10.1016/j.ophtha.2010.03.045.

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Heier JS, Korobelnik JF, Brown DM, Schmidt-Erfurth U, Do DV, Midena E, et al. Intravitreal aflibercept for diabetic macular edema: 148-week results from the VISTA and VIVID Studies. Ophthalmology 2016; 123:2376-85. doi: 10.1016/j.ophtha.2016.07.032.

Maggio E, Sartore M, Attanasio M, Maraone G, Guerriero M, Polito A, et al. Anti-vascular endothelial growth factor treatment for diabetic macular edema in a real-world clinical setting. Am J Ophthalmol. 2018; 195:209-22. doi: 10.1016/j.ajo.2018.08.004.

Ozturk BT, Bozkurt B, Kerimoglu H, Okka M, Kamis U, Gunduz K. Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness. Mol Vis. 2009; 15:1906-14.

Funatsu H, Noma H, Mimura T, Eguchi S, Hori S. Association of vitreous inflammatory factors with diabetic macular edema. Ophthalmology. 2009; 116:73-9. doi: 10.1016/j.ophtha.2008.09.037.

Brito P, Costa J, Gomes N, Costa S, Correia-Pinto J, Silva R. Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF. J Diabetes Complications. 2018; 32:643-9. doi: 10.1016/j.jdiacomp.2018.05.006.

Brito P, Costa J, Gomes N, Costa S, Correia-Pinto J, Silva R. Serum pro-inflammatory factors as predictors of persistent diabetic macular oedema with limited anatomic response to anti-VEGF: association with intravitreal injection treatment profiles in real-world setting. Acta Ophthalmol. 2020; 98:e421-e427. doi: 10.1111/aos.14308.

Brito PS, Costa JV, Barbosa-Matos C, Costa SM, Correia-Pinto J, Silva RM. Association of serum vasogenic and proinflammatory factors with clinical response to anti-vascular endothelial growth factor for diabetic macular edema. Retina. 2021; 41:345-54. doi: 10.1097/IAE.0000000000002852.

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Published

2021-06-30

How to Cite

Brito, P. S., Correia Pinto, J., & Silva, R. (2021). Evaluation of the Systemic Pro-Inflammatory Response Associated with Diabetic Retinopathy as a Limiting Factor on the Efficacy of Intravitreal Treatment for Diabetic Macular Edema. Revista Sociedade Portuguesa De Oftalmologia, 45(2), 117–120. https://doi.org/10.48560/rspo.24503

Issue

Vol. 45 No. 2 (2021)

Section

Flash Look

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