Evaluation of the Systemic Pro-Inflammatory Response Associated with Diabetic Retinopathy as a Limiting Factor on the Efficacy of Intravitreal Treatment for Diabetic Macular Edema

Authors

  • Pedro Silva Brito Opthalmology Department, Hospital de Braga, Braga, Portugal; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, Portugal
  • Jorge Correia Pinto Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, Portugal; ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
  • Rufino Silva Department of Ophthalmology. Centro Hospitalar e Universitario de Coimbra (CHUC), Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research. Faculty of Medicine.University of Coimbra (iCBR- FMUC, Coimbra, Portugal); Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal

DOI:

https://doi.org/10.48560/rspo.24503

Keywords:

Diabetic Retinopathy, Macular Edema, Vascular Endothelial Growth Factor A

Abstract

        

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References

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Tolentino MJ, Miller JW, Gragoudas ES, Jakobiec FA, Flynn E, Chatzistefanou K, et al. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology. 1996; 103:1820-28. doi: 10.1016/s0161-6420(96)30420-x.

Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology. 2010; 117:1078-86;1072. doi: 10.1016/j.ophtha.2010.03.045.

Brown DM, Nguyen QD, Marcus DM, Boyer DS, Patel S, Feiner L, et al. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology. 2013; 120:2013-22. doi: 10.1016/j.ophtha.2013.02.034.

Heier JS, Korobelnik JF, Brown DM, Schmidt-Erfurth U, Do DV, Midena E, et al. Intravitreal aflibercept for diabetic macular edema: 148-week results from the VISTA and VIVID Studies. Ophthalmology 2016; 123:2376-85. doi: 10.1016/j.ophtha.2016.07.032.

Maggio E, Sartore M, Attanasio M, Maraone G, Guerriero M, Polito A, et al. Anti-vascular endothelial growth factor treatment for diabetic macular edema in a real-world clinical setting. Am J Ophthalmol. 2018; 195:209-22. doi: 10.1016/j.ajo.2018.08.004.

Ozturk BT, Bozkurt B, Kerimoglu H, Okka M, Kamis U, Gunduz K. Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness. Mol Vis. 2009; 15:1906-14.

Funatsu H, Noma H, Mimura T, Eguchi S, Hori S. Association of vitreous inflammatory factors with diabetic macular edema. Ophthalmology. 2009; 116:73-9. doi: 10.1016/j.ophtha.2008.09.037.

Brito P, Costa J, Gomes N, Costa S, Correia-Pinto J, Silva R. Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF. J Diabetes Complications. 2018; 32:643-9. doi: 10.1016/j.jdiacomp.2018.05.006.

Brito P, Costa J, Gomes N, Costa S, Correia-Pinto J, Silva R. Serum pro-inflammatory factors as predictors of persistent diabetic macular oedema with limited anatomic response to anti-VEGF: association with intravitreal injection treatment profiles in real-world setting. Acta Ophthalmol. 2020; 98:e421-e427. doi: 10.1111/aos.14308.

Brito PS, Costa JV, Barbosa-Matos C, Costa SM, Correia-Pinto J, Silva RM. Association of serum vasogenic and proinflammatory factors with clinical response to anti-vascular endothelial growth factor for diabetic macular edema. Retina. 2021; 41:345-54. doi: 10.1097/IAE.0000000000002852.

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Published

2021-06-30

How to Cite

Brito, P. S., Correia Pinto, J., & Silva, R. (2021). Evaluation of the Systemic Pro-Inflammatory Response Associated with Diabetic Retinopathy as a Limiting Factor on the Efficacy of Intravitreal Treatment for Diabetic Macular Edema. Revista Sociedade Portuguesa De Oftalmologia, 45(2), 117–120. https://doi.org/10.48560/rspo.24503

Issue

Vol. 45 No. 2 (2021)

Section

Flash Look

License

CC BY

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