Microperimetry in Central Serous Chorioretinopathy - Study of the fellow eye and affected eye after PDT

Abstract

Aims: To find whether microperimetry (MP) detects changes of the fellow eye in Central Serous Chorioretinopathy (CSC); and to study the impact of photodynamic therapy (PDT) upon Macular Sensitivity (MS) of the affected eye. Study design: prospective, observational. Patients and methods: 28 patients with unilateral CSC and Best Corrected Visual Acuity of 20/20 in the fellow eye were included; and subdivided into a Past CSC (OCT-assessed resolution for ≥ 6 months) and an Active CSC Group. MP of the central 10o was performed in both eyes. A control group of 18 eyes (18 individuals) was assembled. Results: Active and Past CSC groups were composed of 4 and 24 patients, respectively. MS in the study group overall was 18.46 +/- 1.28 dB; and 18.77 +/- 1.28 dB in the control group (p=0.305). In the Past CSC group, the difference between MS in the fellow eye (18.5dB +/- 1.2 dB) and affected eye (15.1 +/- 3.2 dB) was significant (p < 0.0001). This difference was still evident in those who recovered 20/20 vision (p = 0.005). The MS gap between fellow eye and CSC eye was not signi- ficantly different (p=0.275) between the PDT group (2.90 +/-2.77 dB) and the group that was not treated (4.23 +/- 2.78 dB). Conclusions: Our study did not reveal subclinical changes in the fellow eye of CSC patients. CSC apparently produces a lasting lesion to the macula, even when visual acuity recovers. PDT may not help decrease the impact of CSC.