The Mesolimbic Dopaminergic Dysfunction in Psychosis: A Review of the Literature
DOI:
https://doi.org/10.25752/psi.6021Keywords:
Acetylcholine Nicotinic Receptors, Dopamine System, KCNQ Potassium Channels, Mesolimbic Pathway, Neurotransmitter Peptides, Psychosis, Phosphodiesterase 10A, SchizophreniaAbstract
Background: For several decades now it is thought that dopamine hyperactivity on the mesolimbic pathway is implied on the genesis of schizophrenic psychotic symptoms.Aims: In this review we sought to interconnect the various areas of current knowledge, seeking to relate them to clinical practice.
Methods: A systematic English language PUBMED search was done, using MeSH (medical subject headings) terms “mesolimbic” and “psychosis”, until April 2014, including reviews.
Results and Conclusions: We found 111 papers, and excluded 56 after an abstract review. We selected 14 papers of the remaining 55. We present evidence on the part played by the neurodevelopment, acetylcholine nicotinic receptor regulation, influence of KCNQ potassium channels, neurotransmitter peptides, adenosine and phosphodiesterase 10A, as well as advances on understanding the etiology of schizophrenia on the development of psychotic symptoms associated not only with this disease but also with several disturbances on which they can occur, as well as a possible relation between these various influences, where it has been possible to do so. It is, therefore, an enunciation of the neurobiological substrate underlying psychotic symptoms.
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