Pseudoangiomatous Stromal Hyperplasia in Pedia¬tric Age: A Case Report and Review of Literature


  • Sara Pinto Magalhães Centro Hospitalar do Porto
  • Filipa Moreno Centro Hospitalar do Porto
  • Nuno Dias Alves Centro Hospitalar do Porto
  • José Miguel Preza Centro Hospitalar do Porto
  • Manuela Certo Centro Hospitalar do Porto
  • Fernanda Reis Centro Hospitalar do Porto



Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign disease, characterized by abnormal proliferation of fibroglandular stroma. It was first described in 1986. The authors present a case of a twelve year-old girl with a history of kidney transplantation due to nephrotic syndrome with rapidly progressive and painful breast asymmetry with approximately six months duration. No lymphadenopathy or other signs or symptoms were associated. Ultrasound didn’t reveal specific findings. Breast magnetic resonance (MR) showed a massive heterogeneous nodular mass with regular contours and contrast enhancement. Given the degree of breast asymmetry as well as the patient’s symptoms, surgical excision of the tumor was preferred over core biopsy. Histopathological and immunohistochemical examination showed pseudoangiomatous stromal hyperplasia. The authors describe the clinical presentation, imaging and histological features as well as therapeutic approach in these patients

Biografias Autor

Sara Pinto Magalhães, Centro Hospitalar do Porto

Serviço de Radiologia

Filipa Moreno, Centro Hospitalar do Porto

Serviço de Anatomia Patológica

Nuno Dias Alves, Centro Hospitalar do Porto

Serviço de Radiologia

José Miguel Preza, Centro Hospitalar do Porto

Serviço de Cirurgia Geral

Manuela Certo, Centro Hospitalar do Porto

Serviço de Radiologia

Fernanda Reis, Centro Hospitalar do Porto

Serviço de Radiologia


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