Pseudoangiomatous Stromal Hyperplasia in Pedia¬tric Age: A Case Report and Review of Literature
DOI:
https://doi.org/10.25748/arp.12004Resumen
Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign disease, characterized by abnormal proliferation of fibroglandular stroma. It was first described in 1986. The authors present a case of a twelve year-old girl with a history of kidney transplantation due to nephrotic syndrome with rapidly progressive and painful breast asymmetry with approximately six months duration. No lymphadenopathy or other signs or symptoms were associated. Ultrasound didn’t reveal specific findings. Breast magnetic resonance (MR) showed a massive heterogeneous nodular mass with regular contours and contrast enhancement. Given the degree of breast asymmetry as well as the patient’s symptoms, surgical excision of the tumor was preferred over core biopsy. Histopathological and immunohistochemical examination showed pseudoangiomatous stromal hyperplasia. The authors describe the clinical presentation, imaging and histological features as well as therapeutic approach in these patientsCitas
Adolescent Breast Masses: A Review of Pathophysiology, Imaging, Diagnosis, and Treatment. AJR. 2013;200:W204–W12.
Marco Ferreira, Constance T Albarracin, Erika Resetkova. Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Modern Pathology. 2008;21:201-7.
Naruto Taira, Shozo Ohsumi, Kenjiro Aogi, et al. Nodular Pseudoangiomatous Stromal Hyperplasia of Mammary Stroma in a Case Showing Rapid Tumor Growth. Breast Cancer. 2005;12(4).
Ellen M. Chung, , Regino Cube, Gregory J. Hall, et al. Breast Masses in Children and Adolescents: Radiologic-Pathologic Correlation. Radiographics. 2009;29(3).
Abid Irshad, Susan J Ackerman, Thomas L Pope, et al. Rare Breast Lesions: Correlation of Imaging and Histologic Features with WHO Classification. Radiographics. 2008;28(5).
Katie N Jones. Imaging of the Adolescent Breast. Semin Plast Surg. 2013;27(1):29-35.
Ekaterini Solomou, Pantelis Kraniotis, and Georgios Patriarcheas. A case of a giant pseudoangiomatous stromal hyperplasia of the breast: magnetic resonance imaging findings. Rare Tumors. 2012;4(2):e23.