IgG4-related disease presenting as mass-like sclerosing mesenteritis

Abstract

IgG4‑related disease (IgG4‑RD) is a newly recognized entity that includes a group of immune-mediated fibro-inflammatory conditions. It can affect a wide range of organs, producing a broad spectrum of presentations. The selection of imaging modality is based on patient symptoms and the organs under evaluation. The diagnosis is based on a combination of radiological findings, elevation serum IgG4 levels, histopathological features, association with other IgG4-related diseases, and response to steroids.

We report a rare case of an IgG4-related sclerosing mesenteritis in a man who presented with an incidental right lower quadrant mesenteric mass and was unsuccessfully treated with corticoids. Isolated mesentery involvement is a rare presentation of IgG4-related disease and only few cases were reported in literature.