Fibrodysplasia ossificans progressive: Stone man syndrome

Abstract

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare and severely disabling genetic disease characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone. Radiologic evaluation is essential for accurate diagnosis, and also for assessing progression and response to therapy. We present a case and describe the imaging features of a 22-year-old woman with FOP.