Solitary fibrous tumor of the breast: a rare case

Abstract

A solitary fibrous tumor (SFT) is a rare neoplasm often found in the pleura. Breast SFT is extremely rare, with just a few cases reported in the literature.

The 49-year-old woman presented with a palpable lump in right breast. Mammography revealed an oval circumscribed mass which on ultrasound corresponded to a well-defined hypoechoic nodule. The imaging findings are not pathognomonic, therefore definitive diagnosis requires histological examination and immunohistochemical analysis.

Histologically, neoplastic cells may adopt spindle to ovoid morphology, and the growth pattern is variable. In the immunohistochemical study, the tumor cells are characterized by strong and diffuse positivity for CD34 and STAT-6.

In conclusion, breast SFT is rare. Histology may show overlapping characteristics with other conditions, with STAT-6 being a sensitive and specific marker that makes the definitive diagnosis. Surgical resection is the gold standard treatment. Although most have a benign and indolent clinical course, long-term follow-up is recommended.