Angiomatoid Fibrous Histiocytoma: A Rare Tumor and a Diagnostic Challenge

Résumé

Angiomatoid Fibrous Histiocytoma (AFH) is a rare soft tissue neoplasm that often presents in the subcutaneous or deep dermis of the extremities of children and young adults and is classified according to the WHO Classification of Soft Tissue Tumors 2020 as "intermediate tumor of uncertain differentiation". Diagnosing this condition is challenging for radiologists and pathologists because of its nonspecific and heterogeneous imaging and histopathologic features.

The authors present a case of a 13-year-old girl with a slow-growing palpable lump in the right thigh, painless, tender, and nonmobile, that on MRI was well-defined, with pseudocapsule and lobulated contours, with fluid-fluid levels with hemorrhagic content and a solid enhancing nodule. Due to the nonspecific imaging features favorable to a malignant lesion, a percutaneous biopsy was performed, and the result was inconclusive. The final diagnosis of AFH was made after surgical excision of the lesion.