Pancreatitis and diabetic ketoacidosis in an adolescent treated with sertraline

Authors

  • Ana Maria Ferreira Department of Pediatrics, Centro Hospitalar Entre-Douro-e-Vouga
  • Joana Caldeira Santos Department of Pediatric Endocrinology and Diabetology Unit, Centro Hospitalar Vila Nova de Gaia/Espinho
  • Sofia Ferreira Department of Pediatric Endocrinology and Diabetology Unit, Centro Hospitalar Vila Nova de Gaia/Espinho
  • Ana Luísa Leite Department of Pediatric Endocrinology and Diabetology Unit, Centro Hospitalar Vila Nova de Gaia/Espinho
  • Rosa Arménia Campos Department of Pediatric Endocrinology and Diabetology Unit, Centro Hospitalar Vila Nova de Gaia/Espinho

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v29.i4.17934

Keywords:

acute pancreatitis, adolescent, diabetic ketoacidosis, sertraline, thyroiditis

Abstract

Acute pancreatitis (AP) is a rare entity in pediatric age. Reports of AP in the context of diabetic ketoacidosis (DKA) have established the role of transient hyperlipemia as a consequent factor.
Pharmacological etiology is responsible for 0.3−1.4% of AP cases, with no case reports of an association with the use of sertraline in the pediatric population to date.
Herein is described the case of a 15-year-old girl with poorly controlled type 1 diabetes, taking sertraline for a depressive disorder, who developed AP associated with DKA.
With this report, the authors intend to emphasize the importance of diagnosing AP in DKA setting. In addition, since the patient had normal serum triglyceride levels and no other risk factors for AP, it is hypothesized that sertraline may have been a triggering event in this context.

Downloads

Download data is not yet available.

References

Srinath AI, Lowe ME. Pediatric pancreatitis. Pediatr. Rev. 2013; 34:79–90.

Jones MR, Hall OM, Kaye AM, Kaye AD. Drug-induced acute pancreatitis: A review. Ochsner J. 2015; 15:45–51.

Uc A, Husain SZ. Pancreatitis in Children. Gastroenterology [Internet]. 2019; 156:1969–78. Available from: https://doi.org/10.1053/j.gastro.2018.12.043.

Della Corte C, Faraci S, Majo F, Lucidi V, Fishman DS, Nobili V. Pancreatic disorders in children: New clues on the horizon. Dig. Liver Dis. [Internet]. 2018; 50:886–93. Available from: https://doi.org/10.1016/j.dld.2018.06.016.

Bialo SR. Rare complications of pediatric diabetic ketoacidosis. World J. Diabetes. 2015; 6:167.

Nair S, Yadav D, Pitchumoni CS. Association of diabetic ketoacidosis and acute pancreatitis: Observations in 100 consecutive episodes of DKA. Am. J. Gastroenterol. 2000; 95:2795–800.

Wolfgram PM, MacDonald MJ. Severe hypertriglyceridemia causing acute pancreatitis in a child with new onset type I diabetes mellitus presenting in ketoacidosis. J. Pediatr. Intensive Care. 2013; 2:77–80.

Kim JH, Oh MJ. Acute Pancreatitis Complicated with Diabetic Ketoacidosis in a Young Adult without Hypertriglyceridemia: A Case Report. Korean J. Gastroenterol. 2016; 68:274–8.

Haddad NG, Croffie JM, Eugster EA. Pancreatic enzyme elevations in children with diabetic ketoacidosis. J. Pediatr. 2004; 145:122–4.

Malbergier A, De Oliveira HP. Sertralina e pancreatite aguda: Relato de caso. Rev. Bras. Psiquiatr. 2004; 26:39–40.

Silva MA, Key S, Han E, Malloy MJ. Acute pancreatitis associated with antipsychotic medication: Evaluation of clinical features, treatment, and polypharmacy in a series of cases. J. Clin. Psychopharmacol. 2016; 36:169–72.

Silva M, Sampaio D. Antidepressivos e suicídio nos adolescentes. Acta Med. Port. 2011; 24:603–12.

Downloads

Published

2020-11-26

How to Cite

1.
Ferreira AM, Santos JC, Ferreira S, Leite AL, Campos RA. Pancreatitis and diabetic ketoacidosis in an adolescent treated with sertraline. REVNEC [Internet]. 2020Nov.26 [cited 2024Sep.1];29(4):209-11. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/17934

Issue

Section

Case Reports

Most read articles by the same author(s)

1 2 > >>