Minimally invasive surfactant therapy in preterm infants: towards less invasive management

Authors

  • Daniel Meireles Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Luísa Neiva Araújo Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Marta Nascimento Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Liliana Pinho Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Ana Cristina Freitas Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Alexandra Almeida Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Carmen Carvalho Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Elisa Proença Neonatal Intensive Care Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v30.i1.19182

Keywords:

INSURE, MIST, preterm, surfactant, ventilation

Abstract

Introduction: Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique.

Material and methods: Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant.

Results: Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (p=0.480), birth weight (p=0.299), fraction of inspired oxygen (FiO2) prior to surfactant (p=0.220), oxygen therapy duration (p=0.306), progression to intubation (p=0.712), or length of Neonatal Intensive Care Unit stay (p=0.778). FiO2 variation before and after surfactant administration was higher in MIST group (14% vs 9%, p=0.078). No significant complications were reported with either technique.

Conclusions: MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO2 requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants.

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Published

2021-04-06

How to Cite

1.
Meireles D, Araújo LN, Nascimento M, Pinho L, Freitas AC, Almeida A, Carvalho C, Proença E. Minimally invasive surfactant therapy in preterm infants: towards less invasive management. REVNEC [Internet]. 2021Apr.6 [cited 2024Dec.11];30(1):18-25. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/19182

Issue

Vol. 30 No. 1 (2021)

Section

Original Articles

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Copyright (c) 2021 Daniel Meireles, Luísa Neiva Araújo, Marta Nascimento, Liliana Pinho, Ana Cristina Freitas, Alexandra Almeida, Carmen Carvalho, Elisa Proença

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