Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient


  • Maria Eduarda Couto Department of Onco-Hematology, Instituto Português de Oncologia do Porto Francisco Gentil https://orcid.org/0000-0003-2092-0325
  • Tereza Oliva Department of Pediatrics, Instituto Português de Oncologia do Porto Francisco Gentil
  • Pedro Alberto Department of Neurosurgery, Centro Hospitalar e Universitário São João
  • Ana Lebre Department of Infectious Disease, Instituto Português de Oncologia do Porto
  • Armando Pinto Department of Pediatrics, Instituto Português de Oncologia do Porto Francisco Gentil
  • Ana Maia Ferreira Department of Pediatrics, Instituto Português de Oncologia do Porto Francisco Gentil


antifungal, encephalitis, mucormycosis, osteomyelitis,  Rhizopus sp


Aim: Mucormycosis infections are highly lethal in immunosuppressed patients. The authors present a rare case of successful treatment of the condition.

Case description: A 14-year-old male with acute lymphoblastic lymphoma in remission was diagnosed with pansinusitis, cerebral osteomyelitis, and encephalitis with an abscess caused by Rhizopus sp. Neurosurgical drainage, endoscopic sinus surgery, and left eye enucleation were performed, and the patient was simultaneously treated with lipossomal-amphotericin B and posaconazol (later replaced by isavuconazol). However, complications (left frontal lobe herniation and cerebrospinal fluid fistula) ensued, requiring surgical reoperation. Chemotherapy was restarted four months later.

Comments: This is a rare case report, in which early and aggressive surgery, antifungal treatment, and multidisciplinary team work were crucial for the successful outcome.


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How to Cite

Couto ME, Oliva T, Alberto P, Lebre A, Pinto A, Maia Ferreira A. Rhino-orbital-cerebral mucormycosis in a pediatric cancer patient. REVNEC [Internet]. 2021Dec.27 [cited 2022May21];30(4):241-5. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/19758



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