Plasmapheresis in acute disseminated encephalomyelitis associated with anti-MOG antibodies – Two clinical cases

Authors

  • Joana Soares Department of Neonatology and Pediatrics, Centro Hospitalar do Tâmega e Sousa
  • Rafael Figueiredo Department of Pediatrics, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto https://orcid.org/0000-0002-4456-2975
  • Eduarda Pinto Department of Neuroradiology, Centro Hospitalar Universitário do Porto
  • Ana Lúcia Cardoso Department of Neonatal and Pediatric Intensive Care, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto https://orcid.org/0000-0002-1575-5006
  • Alzira Sarmento Department of Neonatal and Pediatric Intensive Care, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto https://orcid.org/0000-0002-5397-0057
  • Maria Sameiro Faria Pediatric Nephrology Unit, Department of Pediatrics, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Sónia Figueiroa Neuropediatris Unit, Department of Pediatrics, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto
  • Paula Ferreira Department of Neonatal and Pediatric Intensive Care, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto https://orcid.org/0000-0001-8184-5870

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v31.i2.25273

Keywords:

acute disseminated encephalomyelitis, demyelinating diseases, anti-MOG antibody, neurologic signs

Abstract

Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disorder of the central nervous system. ADEM should be suspected when a patient develops multifocal neurologic abnormalities with encephalopathy, especially if occurring after a viral infection or immunization. In this study, the authors describe two cases of ADEM with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibodies requiring hospitalization in a Pediatric Intensive Care Unit and plasmapheresis treatment.

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References

Lotze TE, Chadwick DJ. Acute disseminated encephalomyelitis (ADEM) in children: Pathogenesis, clinical features, and diagnosis. November 2019 (Consulted in June 2020). Available: https://www.uptodate.com/contents/acute-disseminated-encephalomyelitis-adem-in-children-pathogenesis-clinical-features-and-diagnosis.

Lotze TE, Chadwick DJ. Acute disseminated encephalomyelitis (ADEM) in children: Treatment and prognosis. November 2019 (Consulted in June 2020). Available: https://www.uptodate.com/contents/acute-disseminated-encephalomyelitis-adem-in-children-treatment-and-prognosis.

Brito MJ, Luís C, Silva R, Gouveia C, Vieira JP. Encefalites - Recomendações da Sociedade de Infecciologia Pediátrica e da Sociedade Portuguesa de Neuropediatria. Acta Pediatr Port 2011:42(6):284-91.

Hussein O, Minagar A. Acute Disseminated Encephalomyelitis: Clinical Features, Pathophysiology. Inflammatory Disorders of the Nervous System, Current Clinical Neurology. Springer International Publishing 2017: 161-73. DOI: http://doi.org/10.1007/978-3-319-51220-4_7.

Silva G, Guimarães TM, Barbosa T, Morais L, Marcelino F, Carrilho I, et al. Encefalomielite Aguda Disseminada – Evolução Atípica. Nascer e crescer. 2009; 18(3): 156-9.

Tenembaum S, Chitnis T, Ness J, Hahn JS; International Pediatric MS Study Group. Acute disseminated encephalomyelitis. Neurology 2007; 2007;68;S23-S36. DOI: http://doi.org/10.1212/01.wnl.0000259404.51352.7f.

Young NP, Weinshenker BG, Lucchinetti CF. Acute Disseminated Encephalomyelitis: Current Understanding and Controversies. Semin Neurol. 2008; 28(1): 84-94. DOI : http://doi.org/10.1055/s-2007-1019130.

Krupp LB, Banwell B, Tenembaum S, for the International Pediatric MS Study Group. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 2007; 17; 68(16 Suppl 2): S7-12. DOI: http://doi.org/ 10.1212/01.wnl.0000259422.44235.a8.

Bruijstens AL, Lechner C, Flet-Berliac L, Deiva K, Neuteboom RF, Hemingway C, et al. E.U. paediatric MOG consortium consensus: Part 1 e Classification of clinical phenotypes of paediatricmyelin oligodendrocyte glycoprotein antibody-associated disorders. European Journal of Paediatric Neurology. 2020; 29:2-13. https://doi.org/10.1016/j.ejpn.2020.10.006.

Baumann M, Bartels F, Finke C, Adamsbaum C, Hacohen Y, Rostásy K. E.U. paediatric MOG consortium consensus: Part 2 e Neuroimaging features of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders, European Journal of Paediatric Neurology. 2020; 29:14-21. https://doi.org/10.1016/j.ejpn.2020.10.002.

Padmanabhan A, Connelly-Smith L, Aqui N, Balogun RA, Klingel R, Meyer E, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue. J Clin Apher. 2019;34: 171–354. https://doi.org/10.1002/jca.21705.

Tripathi PP, Hans R, Sharma RR, Lamba DS, Paul P, Sankhyan N, et al. Role of Plasma Exchange in a Steroid- and IVIG-Refractory Patient with Acute Disseminated Encephalomyelitis: A Case Report. Transfus Med Hemother. 2020;47(5):420-3. https://doi.org/10.1159/000504987.

Borras-Novell C, García Rey E, Perez Baena LF, Jordan Garcia I, Catella Cahiz D, Cambra F. Therapeutic plasma exchange in acute disseminated encephalomyelitis in children. J Clin Apher. 2015;30(6):335-9. https://doi.org/10.1002/jca.21388.

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Published

2022-06-30

How to Cite

1.
Soares J, Figueiredo R, Pinto E, Cardoso AL, Sarmento A, Sameiro Faria M, Figueiroa S, Ferreira P. Plasmapheresis in acute disseminated encephalomyelitis associated with anti-MOG antibodies – Two clinical cases. REVNEC [Internet]. 2022Jun.30 [cited 2022Aug.12];31(2):156-61. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/25273

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