Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v32.i2.26186Keywords:
acromegaly, gigantism, cause, clinical featureAbstract
Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism.
The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction.
GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.
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