Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction

Authors

  • Raquel Vaz de Castro Serviço de Endocrinologia, Diabetes e Metabolismo Hospital de Santa Maria, CHULN – EPE, Lisboa https://orcid.org/0000-0002-9113-8114
  • Joana Faustino epartment of Pediatrics, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central https://orcid.org/0000-0003-4015-5624
  • Florbela Ferreira Department of Endocrinology, Diabetes and Metabolism, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte
  • Lurdes Sampaio Pediatric Endocrinology Unit, Department of Pediatrics Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte https://orcid.org/0000-0003-3026-9820

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v32.i2.26186

Keywords:

acromegaly, gigantism, cause, clinical feature

Abstract

Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism.
The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction.
GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.

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Published

2023-09-14

How to Cite

1.
Vaz de Castro R, Faustino J, Ferreira F, Sampaio L. Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction. REVNEC [Internet]. 2023Sep.14 [cited 2025Mar.14];32(2):103-7. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/26186

Issue

Vol. 32 No. 2 (2023)

Section

Review Articles

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Copyright (c) 2023 Raquel Vaz de Castro, Joana Faustino, Florbela Ferreira, Lurdes Sampaio

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