COVID-19-induced rhabdomyolysis in an adolescent: A rare presentation
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v31.i3.27608Keywords:
COVID-19, muscle, myositis, rhabdomyolysisAbstract
Viral infections are a well-known cause of myositis. The clinical presentation may vary from mild myalgia to severe muscle injury. Coronavirus disease 2019 (COVID-19), a viral respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can be a cause of myositis and of rhabdomyolysis, a rare and severe complication.
A previously healthy 11-year-old female adolescent with COVID-19 presented to the Emergency Department with lower limb pain and inability to walk. The initial laboratory study revealed a marked elevation of muscular enzymes, particularly creatine kinase (13046 UI/L; reference value 149 UI/L). Urine dipstick test reacted positively for hemoglobinuria. The patient started treatment with aggressive intravenous hydration, with progressive clinical and analytical improvement.
Musculoskeletal symptoms associated with COVID-19 are a frequent complaint, with potentially severe complications, such as rhabdomyolysis. A proper and timely diagnosis can prevent further clinical deterioration and enable adequate treatment and follow-up.
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Bhai S, Naddaf E, Dimachkie MM. Overview of viral myositis. Last updated May 31,2022 (Assessed June 15, 2022). Available at: https://www.uptodate.com/contents/overview-of-viral-myositis?source=history_widget.
Tekin E, Akoglu HA. From Influenza to SARS-CoV-2: etiological evaluation of acute benign childhood myositis. Acta Neurol Belg 2022;122(4):1043-1047. https://doi.org/10.1007/s13760-021-01785-0.
Uslu S. Myositis due to COVID-19. Postgrad Med J. 2021;97(1148):399. https://doi.org/10.1136/postgradmedj-2021-139725.
Mughal MS, Kaur IP, Alhashemi R, Rehman R, Du D. Acute viral myositis complicated by rhabdomyolysis: a sole manifestation of COVID-19 infection. J Community Hosp Intern Med Perspect. 2021;11(2):289-291. https://doi.org/10.1080/20009666.2021.1878601.
Saud A, Naveen R, Aggarwal R, Gupta L. COVID-19 and Myositis: What We Know So Far. Curr Rheumatol Rep. 2021;23(8):63 . https://doi.org/10.1007/s11926-021-01023-9.
Case SM, Son MB. COVID-19 in pediatrics. Rheum Dis Clin North Am. 2021;47(4):797-811. https://doi.org/10.1016/j.rdc.2021.07.006.
Cassim F, Soni AJ, Murphy S. Severe acute inflammatory myositis and rhabdomyolysis in paediatric SARS-CoV-2 associated MIS-C (multisystem inflammatory syndrome in children). BMJ Case Rep 2021;14(8):e243112. https://doi.org/10.1136/bcr-2021- 243112.
Zang H, Charmchi Z, Seidman RJ, Anziska Y, Velayudhan V, Perk J. COVID-19 associated myositis with severe proximal and bulbar weakness. Muscle Nerve. 2020;62(3):E57-E60. https://doi.org/10.1002/mus.27003.
Orsucci D, Ienco EC, Nocita G, Napolitano A, Vista M. Neurological features of COVID-19 and their treatment: a review. Drugs Context. 2020;9:2020-5-1. https://doi.org/10.7573/dic.2020-5-1.
Hannah JR, Ali SS, Nagra D, Adas MA, Buazon AD, Galloway JD, et al. Skeletal muscles and COVID-19: a systematic review of rhabdomyolysis and myositis in SARS-CoV-2 infection. Clin Exp Rheumatol. 2022;40(2):329-338. https://doi.org/10.55563/clinexprheumatol/mkfmxt.
Samies NL, Pinninti S, James SH. Rhabdomyolysis and Acute Renal Failure in an Adolescent With Coronavirus Disease 2019. J Pediatric Infect Dis Soc. 2020;9(4):507-509. https://doi.org/10.1093/jpids/piaa083.
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Copyright (c) 2022 Rita Calejo, Joana Queirós; Carla Brandão; Fábio Barroso, Leonilde Machado
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