COVID-19-induced rhabdomyolysis in an adolescent: A rare presentation

Authors

DOI:

https://doi.org/10.25753/BirthGrowthMJ.v31.i3.27608

Keywords:

COVID-19, muscle, myositis, rhabdomyolysis

Abstract

Viral infections are a well-known cause of myositis. The clinical presentation may vary from mild myalgia to severe muscle injury. Coronavirus disease 2019 (COVID-19), a viral respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can be a cause of myositis and of rhabdomyolysis, a rare and severe complication.
A previously healthy 11-year-old female adolescent with COVID-19 presented to the Emergency Department with lower limb pain and inability to walk. The initial laboratory study revealed a marked elevation of muscular enzymes, particularly creatine kinase (13046 UI/L; reference value 149 UI/L). Urine dipstick test reacted positively for hemoglobinuria. The patient started treatment with aggressive intravenous hydration, with progressive clinical and analytical improvement.
Musculoskeletal symptoms associated with COVID-19 are a frequent complaint, with potentially severe complications, such as rhabdomyolysis. A proper and timely diagnosis can prevent further clinical deterioration and enable adequate treatment and follow-up.

Downloads

Download data is not yet available.

References

Bhai S, Naddaf E, Dimachkie MM. Overview of viral myositis. Last updated May 31,2022 (Assessed June 15, 2022). Available at: https://www.uptodate.com/contents/overview-of-viral-myositis?source=history_widget.

Tekin E, Akoglu HA. From Influenza to SARS-CoV-2: etiological evaluation of acute benign childhood myositis. Acta Neurol Belg 2022;122(4):1043-1047. https://doi.org/10.1007/s13760-021-01785-0.

Uslu S. Myositis due to COVID-19. Postgrad Med J. 2021;97(1148):399. https://doi.org/10.1136/postgradmedj-2021-139725.

Mughal MS, Kaur IP, Alhashemi R, Rehman R, Du D. Acute viral myositis complicated by rhabdomyolysis: a sole manifestation of COVID-19 infection. J Community Hosp Intern Med Perspect. 2021;11(2):289-291. https://doi.org/10.1080/20009666.2021.1878601.

Saud A, Naveen R, Aggarwal R, Gupta L. COVID-19 and Myositis: What We Know So Far. Curr Rheumatol Rep. 2021;23(8):63 . https://doi.org/10.1007/s11926-021-01023-9.

Case SM, Son MB. COVID-19 in pediatrics. Rheum Dis Clin North Am. 2021;47(4):797-811. https://doi.org/10.1016/j.rdc.2021.07.006.

Cassim F, Soni AJ, Murphy S. Severe acute inflammatory myositis and rhabdomyolysis in paediatric SARS-CoV-2 associated MIS-C (multisystem inflammatory syndrome in children). BMJ Case Rep 2021;14(8):e243112. https://doi.org/10.1136/bcr-2021- 243112.

Zang H, Charmchi Z, Seidman RJ, Anziska Y, Velayudhan V, Perk J. COVID-19 associated myositis with severe proximal and bulbar weakness. Muscle Nerve. 2020;62(3):E57-E60. https://doi.org/10.1002/mus.27003.

Orsucci D, Ienco EC, Nocita G, Napolitano A, Vista M. Neurological features of COVID-19 and their treatment: a review. Drugs Context. 2020;9:2020-5-1. https://doi.org/10.7573/dic.2020-5-1.

Hannah JR, Ali SS, Nagra D, Adas MA, Buazon AD, Galloway JD, et al. Skeletal muscles and COVID-19: a systematic review of rhabdomyolysis and myositis in SARS-CoV-2 infection. Clin Exp Rheumatol. 2022;40(2):329-338. https://doi.org/10.55563/clinexprheumatol/mkfmxt.

Samies NL, Pinninti S, James SH. Rhabdomyolysis and Acute Renal Failure in an Adolescent With Coronavirus Disease 2019. J Pediatric Infect Dis Soc. 2020;9(4):507-509. https://doi.org/10.1093/jpids/piaa083.

Downloads

Published

2022-10-19

How to Cite

1.
Calejo R, Queirós J, Brandão C, Barroso F, Machado L. COVID-19-induced rhabdomyolysis in an adolescent: A rare presentation. REVNEC [Internet]. 2022Oct.19 [cited 2022Dec.7];31(3):317-20. Available from: https://revistas.rcaap.pt/nascercrescer/article/view/27608

Most read articles by the same author(s)