Benign transient HIPERPHOSPHATASEMIA of infancy and childhood and CAMPYLOBACTER JEJUNI infection


  • Cláudia Aguiar Paediatric Service of Centro Hospitalar de São João
  • Juliana Oliveira Paediatric Service of Centro Hospitalar de São João
  • Alexandra Pinto Paediatric Service of Hospital Santa Maria, Centro Hospitalar Lisboa Norte
  • Andreia Eiras Family Medicine of Unidade de Saúde Familiar Rainha D. Amélia
  • Conceição Casanova Paediatric Service of Centro Hospitalar Póvoa de Varzim/ Vila do Conde
  • Maria José Dinis Paediatric Service of Centro Hospitalar Póvoa de Varzim/ Vila do Conde



Campylobacter jejuni, alkaline phosphatase, transient hyperphosphatasemia, infection


Introduction: Benign Transient Hyperphosphatasemia (BTH) is characterised by transient elevation of serum alkaline phosphatase (ALP) in the absence of liver or bone disease. It has been associated to several entities, namely infections.

Case report: We describe the case of a healthy two-year-old child with intermittent episodes of fever, abdominal pain, vomiting and soft stool since two months ago, with no relevant changes on physical examination. The exams revealed elevated ALP (2474 U/L), with normal liver function, calcium and phosphorus. The stool culture was positive for Campylobacter jejuni. Clinical condition was resolved after antibiotic therapy with azithromycin. Six months later serum ALP values were normal.

Conclusion: The age of presentation, the absence of underlying disease and subsequent normalization of ALP allow the diagnosis of BTH. It isn´t possible, according to the available literature, to guarantee if the infection was the cause of BTH or if it was the reason to perform the analytical study.


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How to Cite

Aguiar C, Oliveira J, Pinto A, Eiras A, Casanova C, Dinis MJ. Benign transient HIPERPHOSPHATASEMIA of infancy and childhood and CAMPYLOBACTER JEJUNI infection. REVNEC [Internet]. 2016Mar.16 [cited 2022Aug.18];25(1):35-7. Available from:



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