Benign transient HIPERPHOSPHATASEMIA of infancy and childhood and CAMPYLOBACTER JEJUNI infection
Keywords:Campylobacter jejuni, alkaline phosphatase, transient hyperphosphatasemia, infection
Introduction: Benign Transient Hyperphosphatasemia (BTH) is characterised by transient elevation of serum alkaline phosphatase (ALP) in the absence of liver or bone disease. It has been associated to several entities, namely infections.
Case report: We describe the case of a healthy two-year-old child with intermittent episodes of fever, abdominal pain, vomiting and soft stool since two months ago, with no relevant changes on physical examination. The exams revealed elevated ALP (2474 U/L), with normal liver function, calcium and phosphorus. The stool culture was positive for Campylobacter jejuni. Clinical condition was resolved after antibiotic therapy with azithromycin. Six months later serum ALP values were normal.
Conclusion: The age of presentation, the absence of underlying disease and subsequent normalization of ALP allow the diagnosis of BTH. It isn´t possible, according to the available literature, to guarantee if the infection was the cause of BTH or if it was the reason to perform the analytical study.
Gualco MD et al. Transient benign hyperphosphatasemia. Journal of Pediatric Gastroenterology and Nutrition 2013;57:167-71.
Huh SY. et al. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009;124:703-9.
Kraut J. Isoenzime studies in transient hyperphosphatasemia of infancy. AJDC 1985;139:736-40.
Tolaymat N, Melo MCN. Benign Transient hyperphosphatasemia of infancy and childhood. South Med J 2000;93.
Pace A, Osinde M. Hiperfosfatasemia transitoria benigna de la infancia. Una aproximación racional. Arch. Argent. Pediatr; 1999; 97: 383.
Alves C, Arruti R. “Hiperfosfatasemia Transitória Benigna da Infância”. Acta Ortopédica Brasileira; 2008; 17: 55-7.
Nuñez MA, Menendez A, Diez M.“Hiperfosfatasemia transitoria de la infancia. Nueve casos y revisión de las aportaciones españolas”.Anales Españoles de Pediatria; 1997; 46: 503-7.
Otero JL et al. Elevated alkaline phosphatase in children: an algorithm to determine when a “wait and see” approach is optimal. Clinical Medicine Insights: pediatrics 2011;5:15-8.
Ranchin B, Villard F, André JL, Canterino I, Said MH, Boisson RC, et al. Transient hyperphosphatasemia after organ transplantation in children. Pediatr Transplant. 2002;6:308-12.
Gennery AR, Peaston RT, Hasan A. Benign transient hyperphosphatasemia of infancy and early childhood following cardiac transplantation. Pediatr Transplant. 1998;2:197-9.
Massey GV, Dunn NL, Heckel JL, Chan JC, Russell EC. Benign transient hyperphosphatasemia in children with leukemia and lymphoma. Clin Pediatr (Phila).1996;35: 501-4.
Kutilek S, Cervickova B, Bebova P, Kmonickova M, Nemec V. Normal bone turnover in transient hyperphosphatasemia. J Clin Res Pediatr Endocrinol 2012;4:154-6.
Marcos JMG, Árias MM, Olavarría FE, Sierra AA. Hiperfosfatasemia transitória benigna: aportacion de 20 nuevos casos. An Esp Pediatr 1996;44:112-6.
How to Cite
Copyright and access
This journal offers immediate free access to its content, following the principle that providing free scientific knowledge to the public provides greater global democratization of knowledge.
The works are licensed under a Creative Commons Attribution Non-commercial 4.0 International license.
Nascer e Crescer – Birth and Growth Medical Journal do not charge any submission or processing fee to the articles submitted.