Lipschütz ulcer as a possible initial manifestation of Epstein-Barr virus infection
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v27.i1.9847Keywords:
Child, Epstein-Barr Virus Infections, Vulvar DiseasesAbstract
Introduction: Lipschütz ulcer is characterized by the rapid onset of painful vulvar ulcerations that typically occurs in sexually inactive adolescent girls, being rare in young children. Although the etiology is unknown, several reports suggest that this entity may be a clinical manifestation of primary infection with Epstein- Barr virus. The diagnosis is made after excluded autoimmune causes, sexually transmitted infections and genital trauma.
Case Report: A twelve-month-old girl, admitted with a history of high fever, vulvar ulceration and acute otitis media. Laboratory investigation, demonstrated an acute Epstein-Barr virus infection and ruled out other causes of acute genital ulceration, including autoimmune diseases. Clinical improvement was observed, with resolution of the genital lesions after six weeks, and no recurrence during the ten-month follow-up.
Comments: In conclusion if the most common causes of genital ulcer are excluded and there is no sexual contact, Lipschütz ulcer should be included in the differential diagnosis.
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References
Lipschutz B. Ulcus vulvae acutum. Handbuch der Haut und Geschl. 1927; 21:392-414.
Sidbury R, Levy M. Acute genital ulceration (Lipschutz ulcer). UpToDate. 2014 Sep.
Reymundo M, Salas A. Úlcera de Lipschutz: causa poco conocida de úlcera genital aguda. An Pediatr. 2010; 72: 443-4.
Farhi D, Wendling J, Molinari E, et al. Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study. Arch Dermatol 2009; 145:38.
Jerdan K, Aronson I, Hernandez C, et al. Genital ulcers associated with Epstein-Barr vírus. Cutis 2013; 91:273.
Marcus S, Neill S. Unusual presentation of acute vulvar ulceration. Trends in Urology Gynaecology & Sexual Health. 2008.
Brinca A, Canelas M, Carvalho M. Lipschutz ulcer (ulcus vulvae acutum) – uma causa rara de lesão genital. An Bras Dermatol. 2012; 87:622-4.
Taylor S, Droke SM, Dedicoat M. Genital ulcers associated with acute Epstein-Barr virus infection. Sex Transm Infect. 1998; 74:296-7.
Halvorsen JA, Brevig T. Genital ulcers as initial manifestation of Epstein-Barr vírus infection: two new cases and a review of the literature. Acta Derm Venereol. 2006; 86:439-42
Sárdy M, Wollenberg A, Niedermeler A. Genital ulcers associated with Epstein-Barr vírus infection (Ulcus Vulvae Acutum). Acta Derm Venereol 2011; 91:55-9.
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