Plasmaferese na encefalomielite aguda disseminada associada a anticorpos anti-MOG – Dois casos clínicos
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v31.i2.25273Palavras-chave:
anticorpo anti-MOG, doenças desmielinizantes, encefalomielite aguda disseminada, sinais neurológicosResumo
A encefalomielite aguda disseminada (ADEM) é uma doença desmielinizante aguda do sistema nervoso central. O diagnóstico de ADEM deve ser considerado quando o doente apresenta alterações neurológicas focais associadas a encefalopatia, sobretudo se as manifestações surgem após uma infeção vírica ou vacinação. Neste artigo, são descritos dois casos clínicos de ADEM com anticorpos anti-MOG positivos com necessidade de internamento em Unidade de Cuidados Intensivos Pediátricos e tratamento com plasmaferese.
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Lotze TE, Chadwick DJ. Acute disseminated encephalomyelitis (ADEM) in children: Pathogenesis, clinical features, and diagnosis. November 2019 (Consulted in June 2020). Available: https://www.uptodate.com/contents/acute-disseminated-encephalomyelitis-adem-in-children-pathogenesis-clinical-features-and-diagnosis.
Lotze TE, Chadwick DJ. Acute disseminated encephalomyelitis (ADEM) in children: Treatment and prognosis. November 2019 (Consulted in June 2020). Available: https://www.uptodate.com/contents/acute-disseminated-encephalomyelitis-adem-in-children-treatment-and-prognosis.
Brito MJ, Luís C, Silva R, Gouveia C, Vieira JP. Encefalites - Recomendações da Sociedade de Infecciologia Pediátrica e da Sociedade Portuguesa de Neuropediatria. Acta Pediatr Port 2011:42(6):284-91.
Hussein O, Minagar A. Acute Disseminated Encephalomyelitis: Clinical Features, Pathophysiology. Inflammatory Disorders of the Nervous System, Current Clinical Neurology. Springer International Publishing 2017: 161-73. DOI: http://doi.org/10.1007/978-3-319-51220-4_7.
Silva G, Guimarães TM, Barbosa T, Morais L, Marcelino F, Carrilho I, et al. Encefalomielite Aguda Disseminada – Evolução Atípica. Nascer e crescer. 2009; 18(3): 156-9.
Tenembaum S, Chitnis T, Ness J, Hahn JS; International Pediatric MS Study Group. Acute disseminated encephalomyelitis. Neurology 2007; 2007;68;S23-S36. DOI: http://doi.org/10.1212/01.wnl.0000259404.51352.7f.
Young NP, Weinshenker BG, Lucchinetti CF. Acute Disseminated Encephalomyelitis: Current Understanding and Controversies. Semin Neurol. 2008; 28(1): 84-94. DOI : http://doi.org/10.1055/s-2007-1019130.
Krupp LB, Banwell B, Tenembaum S, for the International Pediatric MS Study Group. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 2007; 17; 68(16 Suppl 2): S7-12. DOI: http://doi.org/ 10.1212/01.wnl.0000259422.44235.a8.
Bruijstens AL, Lechner C, Flet-Berliac L, Deiva K, Neuteboom RF, Hemingway C, et al. E.U. paediatric MOG consortium consensus: Part 1 e Classification of clinical phenotypes of paediatricmyelin oligodendrocyte glycoprotein antibody-associated disorders. European Journal of Paediatric Neurology. 2020; 29:2-13. https://doi.org/10.1016/j.ejpn.2020.10.006.
Baumann M, Bartels F, Finke C, Adamsbaum C, Hacohen Y, Rostásy K. E.U. paediatric MOG consortium consensus: Part 2 e Neuroimaging features of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders, European Journal of Paediatric Neurology. 2020; 29:14-21. https://doi.org/10.1016/j.ejpn.2020.10.002.
Padmanabhan A, Connelly-Smith L, Aqui N, Balogun RA, Klingel R, Meyer E, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue. J Clin Apher. 2019;34: 171–354. https://doi.org/10.1002/jca.21705.
Tripathi PP, Hans R, Sharma RR, Lamba DS, Paul P, Sankhyan N, et al. Role of Plasma Exchange in a Steroid- and IVIG-Refractory Patient with Acute Disseminated Encephalomyelitis: A Case Report. Transfus Med Hemother. 2020;47(5):420-3. https://doi.org/10.1159/000504987.
Borras-Novell C, García Rey E, Perez Baena LF, Jordan Garcia I, Catella Cahiz D, Cambra F. Therapeutic plasma exchange in acute disseminated encephalomyelitis in children. J Clin Apher. 2015;30(6):335-9. https://doi.org/10.1002/jca.21388.
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Direitos de Autor (c) 2022 Joana Soares, Rafael Figueiredo, Eduarda Pinto, Ana Lúcia Cardoso, Alzira Sarmento, Maria Sameiro Faria, Sónia Figueiroa, Paula Ferreira
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