Aiming for Single Digit Intraocular Pressure and Drop-Free Surgery in Glaucoma: Trabeculectomy with Mitomycin C and Intracamerular Bevacizumab

Authors

  • Patrícia José Figueiredo Lopes 1 - Department of Ophthalmology, Centro Hospitalar Universitário Lisboa Norte, Portugal; 2 - Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Portugal
  • Rafael Barão 1 - Department of Ophthalmology, Centro Hospitalar Universitário Lisboa Norte, Portugal; 2 - Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Portugal
  • André Barata 1 - Department of Ophthalmology, Centro Hospitalar Universitário Lisboa Norte, Portugal; 2 - Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Portugal; 3 - Centro de Estudos Ciências da Visão, Faculdade de Medicina, Universidade de Lisboa, Portugal
  • Carlos Marques-Neves 1 - Department of Ophthalmology, Centro Hospitalar Universitário Lisboa Norte, Portugal; 2 - Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Portugal; 3 - Centro de Estudos Ciências da Visão, Faculdade de Medicina, Universidade de Lisboa, Portugal
  • José Pedro Silva 4 - Department of Ophthalmology, Hospital dos Lusíadas, Portugal
  • Luís Abegão Pinto 1 - Department of Ophthalmology, Centro Hospitalar Universitário Lisboa Norte, Portugal; 2 - Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Portugal; 3 - Centro de Estudos Ciências da Visão, Faculdade de Medicina, Universidade de Lisboa, Portugal; 4 - Department of Ophthalmology, Hospital dos Lusíadas, Portugal

DOI:

https://doi.org/10.48560/rspo.26219

Keywords:

Bevacizumab, Glaucoma, Intraocular Pressure, Mitomycin, Trabeculectomy

Abstract

INTRODUCTION: Our purpose was to assess patients with single digit intraocular pressure (IOP) values and drop-free in primary trabeculectomy after using mitomycin C (MMC augmented with intracamerular bevacizumab).

MÉTODOS: Retrospective, observational and comparative study. Charts from patients who underwent trabeculectomy and with IOP ≤9 mmHg at the last follow-up were included. Sub-analysis of patients screened between Oct 2015 and Mar 2019, for inclusion criteria of ≤9 mmHg at last follow-up (24 months).

RESULTS: From 110 eyes screened in the initial study, 30 had the intended IOP target (MMC only: 11; MMC+bevacizumab: 19; 26% vs 41%, respectively, odds ratio 1.78, 95% IC (0.80 - 4.89), p=0.178). All these low-IOP patients were drop-free in this moment. No systemic adverse events were found and no vision-threatening complications were recorded.

CONCLUSION: Adding intracamerular bevacizumab to MMC in trabeculectomy can be particularly useful in low-target IOP surgeries (such as normal tension glaucoma or very advanced glaucomas) comparing with trabeculectomy with MMC alone.

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Published

2022-09-30

How to Cite

Lopes, P. J. F., Barão, R., Barata, A., Marques-Neves, C., Silva, J. P., & Abegão Pinto, L. (2022). Aiming for Single Digit Intraocular Pressure and Drop-Free Surgery in Glaucoma: Trabeculectomy with Mitomycin C and Intracamerular Bevacizumab. Revista Sociedade Portuguesa De Oftalmologia, 46(3), 154–159. https://doi.org/10.48560/rspo.26219

Issue

Vol. 46 No. 3 (2022):

Section

Original Article

License

Copyright (c) 2022 Revista Sociedade Portuguesa de Oftalmologia

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