Iridociliary Body Plasmacytoma: A Case-Report and a Focused Review of Literature

Abstract

Extramedullary plasmacytomas associated with multiple myeloma (MM) are rare, and involvement of the eye and adnexae is even rarer, with an incidence of less than 1%. We describe the case of a 56-year-old male, with a history of refractory MM and sacral plasmacytoma, who presented with reduced visual acuity and redness in the right eye. Biomicroscopy revealed an amelanotic temporal and inferotemporal iris mass, involving the anterior chamber angle from 6 to 10 o’clock, with intrinsic vascularization. A presumed diagnosis of iridociliary body plasmacytoma was established, which was later confirmed by fine-needle aspiration biopsy. The tumor responded well to immunochemotherapy, and the patient became asymptomatic. However, despite treatment efforts, the patient passed away shortly after due to widespread systemic MM progression with central nervous system (CNS) involvement. This case highlights the challenges associated with managing extramedullary disease and the need for further research and treatment strategies to address this aggressive manifestation of MM.