PREVALÊNCIA DE COLONIZAÇÃO DE Candida spp. EM ISOLADOS DA MUCOSA ORAL DE PACIENTES ONCOLÓGICOS SUBMETIDOS A TRATAMENTO
DOI:
https://doi.org/10.25746/ruiips.v4.i4.14458Keywords:
Candida spp. Candidíase. Imunossuprimido. Candidiasis. Immunosuppression. CHROMagar.Abstract
RESUMODevido à imunossupressão resultante da quimioterapia e radioterapia, pacientes oncológicos e onco-hematológicos frequentemente apresentam manifestações orais causadas por fungos oportunistas presentes em sua microbiota. A candidíase da mucosa oral, doença oportunista causada por leveduras do gênero Candida, além de ter interferência direta na qualidade de vida do paciente, pode levar a complicações sistêmicas, aumentando os riscos de morbi-mortalidade e os custos do tratamento. O presente estudo teve como objetivo avaliar a frequência de Candida spp. em isolados coletados da mucosa oral de pacientes oncológicos submetidos a tratamento em um hospital público de Varginha-MG. Foram coletadas amostras da mucosa oral de 21 pacientes, por meio de swab estéril, que foram inoculados em caldo BHI com cloranfenicol. As amostras sugestivas de leveduras foram isoladas em Agar Sabourand e a identificação realizada através do meio cromogênico CHROMagar Candida. Das 21 amostras, 12 (57,1%) não apresentaram crescimento e 9 (42,9%) foram positivas para leveduras, sendo sete (77,8%) das amostras pertencentes à C.albicans, uma (11,1%) à C. tropicalis e uma (11,1%) à C. albicans e à C. tropicalis.
ABSTRACT
Immunosuppression resulting from chemotherapy and radiotherapy in oncological and onco-haematological patients often involves oral manifestations caused by opportunistic fungi. The oral candidiasis caused by Candida species, directly affects the life quality of patients and can cause systemic complications, increasing the risk of morbidity and mortality and treatment costs. This study aimed to assesses the prevalence of Candida spp. isolates collected from the oral mucosa of patients undergoing oncological treatment in a public hospital in Varginha-MG. The samples were collected from 21 patients, by swab, inoculated into BHI broth with chloramphenicol. Samples suggestive of yeast were re-inoculated on medium BHI Agar and submitted to identification by CHROMagar Candida to differentiate the species. From the 21 samples, 12 (57.1%) didn’t present growth and 9 (42.9%) were positive for yeasts, where seven samples (77.8%) presented C. albicans, one (11.1%) C. tropicalis and one (11.1%) both C. albicans and C. tropicalis.
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