Guillain-Barré Syndrome underlying SARS-CoV-2 or just a confounding factor?

Authors

DOI:

https://doi.org/10.25751/rspa.20626

Keywords:

Guillain-Barré syndrome, SARS-CoV-2, Covid-19, Mechanical Ventilation

Abstract

Guillain-Barré syndrome was frequently associated with a viral infection. Molecular mimicry is one of the mechanisms through which viruses can be involved in the etiology of this inflammatory demyelinating neuropathy. We describe a case of a 58-year-old man with a diagnosis of SARS-CoV-2 infection who developed clinical symptoms which are coincident with Guillain-Barré syndrome. SARS-CoV-2 could have been the trigger and even though the causative relationship remains unclear, there is a probable cause-effect association between SARS-CoV-2 and GBS, however more studies are needed to support this association.

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References

1. Marina Padron, Vincenzo Mastrangelo, Gian Maria Asioli, Lucia Pavolucci, Samir Abu‑Rumeileh, Maria Grazia Piscaglia et al. Guillain‑Barré syndrome following COVID‑19: new infection, old complication? Journal of Neurology. 24 April 2020. https://doi.org/10.1007/s00415-020-09849-6

2. Ahmed Virani, Erica Rabold, Taylor Hanson, Aaron Haag, Rawiya Elrufay, Tariq Cheema, Marvin Balaan, Nitin Bhanot. Guillain-Barré Syndrome associated with SARS-CoV2 infection. Elsevier 12 April 2020 https://doi.org/10.1016/j.idcr.2020.e00771

3. Gianpaolo Toscano, Francesco Palmerini, Sabrina Ravaglia, Luigi Ruiz, Paolo Invernizzi, M. Giovanna Cuzzoni et al. Guillain-Barré Syndrome associated with SARS-CoV2 infection. N Engl J Med. April 17, 2020. DOI: 10.1056/NEJMc2009191

4. Aggarwal A N, Gupta D, Lal V, Behera D, Jindal S K, Prabhakar S. Ventilatory management of respiratory failure in patients with severe Guillain-Barré syndrome. Neurol India 2003;51:203-205. http://www.neurologyindia.com/text.asp?2003/51/2/203/1083

5. Hua Zhao, Dingding Shen, Haiyan Zhou, Jun Liu, Sheng Chen. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? The Lancet . Vol 19 May 2020 https://doi.org/10.1016/S1474-4422(20)30109-5

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Published

2020-10-06

How to Cite

Romano Ribeiro, C., Alves, A. ., Silva, M., Pipa, S., Figueiredo, S., & Fonseca, T. . (2020). Guillain-Barré Syndrome underlying SARS-CoV-2 or just a confounding factor?. Journal of the Portuguese Society of Anesthesiology, 29(3), 172–173. https://doi.org/10.25751/rspa.20626

Issue

Vol. 29 No. 3 (2020): Revista da Sociedade Portuguesa de Anestesiologia

Section

Case Report

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