Sensitization to dust and storage mites: the increasing prevalence of Lepidoglyphus destructor
Keywords:Lepidoglyphus destructor, mites, sensitization
Introduction: Allergic disease is a leading cause of chronic disease in pediatric age. Dust mites are the most important cause of allergy and there have been seen differences both in their geographical distribution and the sensitization profile.
Aims: The aim of this study was to analyze patterns of domestic and storage mites sensitization in the pediatric population attending the outpatient clinic of an hospital in the northern region of Portugal.
Materials and methods: The study consisted on a retrospective analysis of the clinical records of the patients who were studied by skin prick tests, including commercial extracts of domestic and storage mites in two distinct periods, from January 1st 2010 to December 31st 2011 and from March 1st 2014 to March 31st 2015.
Results: Six hundred and twenty-one children were included. Allergic sensitization was found in 48.3%. Most of them were males (61.3%) and the mean age was 9.7 years. Rhinitis was the most common allergic disease (67%), followed by asthma (51%). The predominant sensitization was to Dermatophagoides pteronyssinus. We found an increase in sensitization rates to storage mites over time, namely to Lepidoglyphus destructor and Glycyphagus domesticus.
Conclusion: An increasing sensitization rate to storage mites has been observed, especially to Lepidoglyphus destructor. Knowledge of this sensitization profile is particularly important to establish effective environmental control measures and manage specific immunotherapy.
Sousa S, Fraga J, Martins V, Quaresma M. Sensibilização a ácaros num grupo de crianças atópicas do interior norte de Portugal. Acta Pediatr Port. 2010; 41:201-4.
Von Mutius E. The burden of childhood asthma. Arch Dis Child. 2000; 82: II2-5.
Platts-Mills TAE, Vervloet D, Thomas WR, Aalberse RC, Chapman, MD. Indoor allergens and asthma: report of the Third International, Workshop. J Allergy Clin Immunol 1997;100:S1-24.
Álvares, E, Doenças Respiratórias – Manual prático, Lidel, Outubro 2006.
Norma nº 061/2011 de 29/12/2011 atualizada a 23/03/2015, Prescrição de Exames Laboratoriais para Avaliação de Doença Alérgica, Direção Geral de Saúde.
Mapa Acarológico de Portugal. Rev Port Imunoalergologia 2009; 17:195-8.
Allergen standardization and skin tests. Position paper. The European Academy of Allergology and Clinical Immunology. Allergy 1993; 48:48-82.
Couto M, Almeida MM. Diagnóstico da doença alérgica em Portugal: Um estudo exploratório. Rev. Port. Imunoalergologia. 2011; 19:23-32.
D’Amato, Cecchi L. Effects of climate change on environmental factors in respiratory allergic diseases. Clinical and Experimental Allergy. 2008; 38:1264–74.
Saulyte J, Regueira C, Montes-Martínez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLoS Med. 2014; 11:e1001611. doi: 10.1371/journal.pmed.1001611.
Arias-Irigoyen J, Lombardero M, Arteaga C, Carpizo JA, Barber D. Limited IgE cross-reactivity between Dermatophagoides pteronyssinus and Glycyphagus domesticus in patients naturally exposed to both mite species. J Allergy Clin Immunol. 2007; 120:98-104.
Arlian LG, Morgan MS, Neal JS. Dust mite allergens: ecology and distribution. Curr Allergy Asthma Rep. 2002; 2:401-11.
Chapman MD, Pones A, Breiteneda H, Ferreira F. Nomenclature and structural biology of allergen. Allergy Clin Immunol 2007; 119:414-20.
Thomas WR, Smith WA, Hales BJ, Mills KL, O’Brien RM. Characterization and immunobiology of house dust mite allergens. Int Arch Allergy Immunol 2002; 129:1-18.
Gafvelin G, Johansson E, Lundin A, Smith AM, Chapman MD, Benjamin DC, et al. Cross reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly D2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepydogliphus destructor and Tyrophagus putrescentiae with recombinant allergens. J Allergy Clin Immunol 2001; 107:511-8.
Van Hage-Hamsten M, Johansson SG, Johansson E, Wiren A. Lack of allergenic cross reactivity between storage mites and Dermatophagoides pteronyssinus. Clin Allergy. 1987;17: 23-31.
Lehtinen PT. Ecology and distribution of mites. Allergy 1985; 40: 30-3.
Tee RD. Allergy to store mites. Clin Exp Allergy. 1994; 24:636-40.
Ebner C, Feldner H, Ebner H, Kraft D. Sensitization to storage mites in house dust mite (Dermatophagoides pteronyssinus) allergic patients. Comparision of a rural and urban population. Clin Exp Allergy 1994; 24:347-52.
Hardel PJ, de Lajudie JP, Portal B, Ville G, Guilloux L, D’Athis P. Allergy to Thyrophagus putrescentiae and Lepidoglyphus destructor in a population of young asthmatic adults. [French] Allerg Immunol (Paris) 1987; 19:399-402, 404-556.
Polo Corrales F. Allergen properties of Lepidoglyphus destructor. J Investig Allergol Clin Immunol 1997; 7:405-6.
Wraight DG, Cunnington AM, Seymor WM. The role and allergenic importance of storage mites in house dust and other environments. Clin Allergy 1979, 9:545-61.
Olsson S, van Hage-Hamsten M. Allergens from house dust and storage mites: similarities and differences, with emphasis on the storage mite Lepidoglyphus destructor. Clin Exp Allergy 2000; 30:912-9.
Garcia-Robaina JC, Eraso E, De la Torre F, Guisantes J, Martinez A, Palacios R, Martinez J. Extracts from various mite species contain cross-reactive and noncross-reactive IgE epitopes. A RAST inhibition study. J Investig Allergol Clin Immunol 1998; 8:285-9.
Luczynska CM, Griffin P, Davies RJ, Topping MD. Prevalence of specific IgE to storage mites (A. siro, L. destructor and T. longior) in an urban population and crossreactivity with the house dust mite (D. pteronyssinus). Clin Exp Allergy 1990; 20:403-6.
Varela J, Ventas P, Carreira J, Barbas JA, Gimenez-Gallego G, Polo F. Primary structure of Lep d I, the main Lepidoglyphus destructor allergen. Eur J Biochem 1994; 225:93-8.
van der Heide S, Niemeijer NR, Hovenga H, de Monchy JG, Dubois AE, Kauffman HF. Prevalence of sensitization to the storage mites Acarus siro, Tyrophagus putrescentiae, and Lepidoglyphus destructor in allergic patients with different degrees of sensitization to the house-dust mite Dermatophagoides pteronyssinus. Allergy 1998; 53:426-30.
How to Cite
Copyright and access
This journal offers immediate free access to its content, following the principle that providing free scientific knowledge to the public provides greater global democratization of knowledge.
The works are licensed under a Creative Commons Attribution Non-commercial 4.0 International license.
Nascer e Crescer – Birth and Growth Medical Journal do not charge any submission or processing fee to the articles submitted.