• Marta Santalha Pediatric Department of U. Guimarães, Centro Hospitalar Alto Ave
  • Filipa Correia Pediatric Department of U. Guimarães, Centro Hospitalar Alto Ave
  • Alberto Costa Pediatric Department of U. Guimarães, Centro Hospitalar Alto Ave
  • Liliana Macedo Pediatric Department of U. Guimarães, Centro Hospitalar Alto Ave
  • Paula Alendouro Immunoallergology Unit , U. Guimarães, CH Alto Ave
  • Águeda Matos Pediatric Department of U. Guimarães, Centro Hospitalar Alto Ave



Child, food hypersensitivity, skin tests


Introduction: Food allergy affects up to 4 -6% of children. Cow’s milk and egg allergy are the main allergies, which are usually transient.

Purpose and methods: To characterize cases of persistent or less frequent food allergies in children followed as outpatient in a Level II Hospital. Diagnosis was based on clinical history, skin prick tests, specific serum IgE, ISAC and Imunoblotting in special situations, and in oral food challenge whenever possible. Egg allergy was excluded. One case of cow’s milk allergy was included because of its persistence beyond infancy.

Results: Twelve cases were selected, 75% (9) were male. There was a family history of allergy in 58.3% (7) and 83.3% (10) had more than one atopic disease. There were seven cases of kiwi fruit allergy and four cases of multiple food hypersensitivity. Clinical presentations were: urticaria [66.7% (8)]; lips edema [63.6% (7)], angioedema [41.7% (6)] and dyspnoea [45.5% (5)]. All skin prick tests were positive, unlike the laboratory tests (case 5:, skin prick tests and oral food challenge positives to the kiwi fruit, with specific serum IgE, immuno solid-phase allergen chip and immunoblotting negatives) Of the five patients who underwent oral food challenge, only one acquired tolerance

Conclusions: In these cases, most children had co-sensitization with other allergens, as well as another manifestation of concomitant allergy, showing the role of food allergy in allergic march. Food allergy diagnosis is extremely important, as it can be potentially serious if not prevented by food avoidance.


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Uguz A, Lack G, Pumphrey R, Ewan P, Warner J, Dick J, et al.

Allergic reactions in the community: a questionnaire survey

of members of the anaphylaxis campaign. Clin Exp Allergy

; 35:746 -50.

Lasley MV, Shapiro GG. Testing For Allergy. Pediatrics in Review

; 21:39 -43.

Sampson HA. Update on food allergy. J Allergy Clin Immunol

; 113:805 -19.

Kolacek S. Food hypersensitivity in children. Acta Med Croatica

; 65:155 -61.

Lucas JS, Lewis SA, Hourihane JO. Kiwi fruit allergy: a review.

Pediatr Allergy Immunol 2003; 14:420 -8.

Almeida MM, Prates S, Pargana E, Arêde C, Godinho N, Tavares

C, et al. Alergia alimentar em crianças numa consulta

de Imunoalergologia. Rev Port Imunoalergol 1999; 7:167 -71.

Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R,

Pongracic J, et al. The Prevalence, Severity, and Distribution

of Childhood Food Allergy in the United States. Pediatrics

: 128:e8 -17.

Minford AM, MacDonald A, Littlewood JM. Food intolerance

and food allergy in children: a review of 68 cases. Arch Dis

Child 1982; 57:742 -7.

Branum AM, Lukacs SL. Food allergy among U.S. children:

Trends in prevalence and hospitalizations. NCHS Data Brief

; 10:1 -8.

Lucas JS, Grimshaw KE, Collins K, Warner JO, Hourihane

JO. Kiwi fruit is a signifi cant allergen and is associated with

differing patterns of reactivity in children and adults. Clin Exp

Allergy 2004; 34:1115 -21.

Aleman A, Quirce S, Carnés J, Férnandez -Caldas E, De Las

Heras M, Sastre J, et al. Kiwi fruit allergy: a double -blind,

placebo -controlled, food challenge study. J Allergy Clin Immunol

; 109:S218 -9.

Sicherer SH, Muñoz -Furlong A, Sampson HA. Prevalence of

seafood allergy in the United States determined by a random

telephone survey. J Allergy Clin Immunol 2004; 114:159 -65.

Sicherer SH, Munoz -Furlong A, Sampson HA. Prevalence of

peanut and tree nut allergy in the United States determined

by means of a random digit dial telephone survey: a 5 -year

follow -up study. J Allergy Clin Immunol 2003; 112:1203 -7.

Position paper. Allergen standardization and skin tests. The

European Academy of Allergology and Clinical Immunology.

Allergy 1993; 48:48 -82.

Kijima A, Murota H, Takahashi A, Arase N, Yang L, Nishioka

M, et al. Prevalence and impact of past history of food allergy

in atopic dermatitis. Allergol Int 2013; 62:105 -12.



How to Cite

Santalha M, Correia F, Costa A, Macedo L, Alendouro P, Matos Águeda. FOOD ALLERGY IN CHILDHOOD. REVNEC [Internet]. 2017Jan.31 [cited 2024Jun.15];22(2):75-9. Available from:



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