Neonatal mastitis: Case series in a neonatal intermediate care unit


  • Beatriz Parreira de Andrade Department of Pediatrics, Centro Hospitalar Médio Ave
  • Raquel Cardoso Department of Pediatrics, Centro Hospitalar Médio Ave
  • Cristina Miguel Department of Pediatrics, Centro Hospitalar Médio Ave
  • Filipa Almeida Department of Pediatrics, Centro Hospitalar Médio Ave



breast exudate, flucloxacillin, neonatal mastitis


Neonatal mastitis is a rare infection of the breast tissue in the newborn. In most cases, it presents unilaterally in the third week of life and has a favorable prognosis. The treatment of choice remains controversial. The aim of this study was to retrospectively review the cases of neonatal mastitis diagnosed and treated in a neonatal intermediate care unit between July 2000 and June 2020.
Ten female neonates with neonatal mastitis were included in the study. The mean age at diagnosis was 22 days. All cases presented with unilateral mastitis and no systemic signs. Staphylococcus aureus was isolated in six cases and was methicillin-resistant in two. Neonates were predominantly treated with intravenous flucloxacillin for a median of 10 days. Four cases presented abscesses, three of which were surgically drained. All infants had a favorable outcome.
The present cases of neonatal mastitis showed similar characteristics to those reported in the literature, namely a higher incidence in females, unilateral presentation, and association with Staphylococcus aureus infection. The authors propose an algorithm for the prompt diagnosis and treatment of this condition, ensuring favorable outcomes by minimizing the risk of sepsis and breast tissue sequelae.


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Jawahar A, Vade A. Sonographic features of physiologic neonatal breast enlargement. J. Clin. Neonatol. 2014; 3: 106-8.

Scolnik D, AL Ruwaili N. Neonatal mastitis: Controversies in management. Journal of Clinical Neonatology. 2012; vol. 1: 207-10.

Silva A, Nirupama K. De, Fortunov R. Mastitis and breast abscess in infants younger than two months. Uptodate, 2022. Accessed on March 05, 2022. Available in:

Panteli C, Arvaniti M, Zavitsanakis A. Long-term consequences of neonatal mastitis. Arch. Dis. Child. 2012; 97: 673–4.

Efrat M, Mogilner J, Iuhtman M, Eldemberg D, Kunin J, Eldar S. Neonatal mastitis-diagnosis and treatment. Isr J Med Sci. 1995; 9: 558-60.

Montague EC, Hilinski J, Andresen D, Cooley A. Pediatr Infect Dis J. 2013;32(11):1295-6.

Masoodi A, Mufti G, Bhat J, Lone R, Arshi S, Ahmad S, Neonatal Mastitis: A Clinic-Microbiological Study, Journal of Neonatal Surgery. 2014; 3 (1): 1-6.

Sloan B, and Evans R, Clinical pearls: Neonatal breast mass. Acad. Emerg. Med. 2003; 10 (3): 269–70.

Brett A, Gonçalves S, Luz A, Martins D, Oliveira H, Januário L, Rodrigues F. Neonatal mastitis: 12 Years of experience, Acta Med. Port.2012; 25 (4): 207–12.

Lee S E, Lee J, Suh E S. Sepsis from Neonatal Mastitis and Breast Abscess. Soonchunhyang Medical Science. 2015; 21 (1): 49–51.

Sharma D, Murki S, Pratap T, Mastitis Neonatorum: An Interesting and Uncommon Condition Seen in Infants. J. Neonatal Biol. 2017; 6 (1):1-2.




How to Cite

Parreira de Andrade B, Cardoso R, Miguel C, Almeida F. Neonatal mastitis: Case series in a neonatal intermediate care unit. REVNEC [Internet]. 2023Sep.14 [cited 2024Jun.20];32(2):132-6. Available from:



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