Hemangioma da Infância
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v25.i2.9519Palavras-chave:
Hemangioma, Malformações vasculares, TratamentoResumo
Os hemangiomas infantis são os tumores mais comuns da infância, ocorrendo em cerca de 3 a 10% das crianças com ida-de inferior a um ano de idade, com predomínio no sexo feminino. Apesar da frequência destes tumores, a sua patogénese permanece pouco compreendida e a melhor abordagem terapêutica é controversa.
Têm uma história natural de crescimento rápido durante a primeira infância, seguida de involução gradual, muitas vezes levando à regressão completa. Devido à sua involução espontânea, a maioria dos hemangiomas infantis não requerem qual-quer intervenção. No entanto, em 10 a 15% dos casos é necessário tratamento devido às possíveis complicações locais, compromisso fisiológico ou estético a longo prazo elevado ou risco de vida.
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Referências
Mulliken JB, Glowacki J. Hemangiomas and vascular
malformations in infants and children: a classification based
on endothelial characteristics. Plast Reconstr Surg. 1982;
:412-22.
ISSVA Classification of vascular anomalies international
society for the study of vascular anomalies.
Vascular tumors and malformations. Habif. Clinical
Dermatology. 5th ed : Mosby, Elsevier, 2009, 23.
Morelli G.M. Vascular Disorders. Kliegman. Nelson Textbook
of Pediatrics. 19th ed. : Saunders, 2011.
Bruckner AL, Frieden IJ. Hemangiomas of infancy. J Am
Acad Dermatol. 2003; 48:477-93.
Finn MC, Glowacki J, Mulliken JB. Congenital vascular
lesions: clinical application of a new classification. J Pediatr
Surg 1983; 18: 894-9.
Hand JL, Frieden IJ. Vascular birthmarks of infancy: resolving
nosologic confusion. Am J Med Genet 2002; 108: 257-64.
C. Léauté-Labrèze, S. Prey, K. Ezzedine. Infantile
haemangioma: Part I. Pathophysiology, epidemiology, clinical
features, life cycle and associated structural abnormalities.
, JEADV, Vols. 25, 1245–53.
Goldsmith L A, Katz S I, Gilchrest B A, Paller A S, Leffell
D J Wolff K. Vascular tumors. Fitzpatrick’s Dermatology in
General Medicine. 7th. ed : MC Graw Hill, 2008, Vol.1.
Chiller KG, Passaro D, Fieden IJ. Hemangiomas of infancy.
Clinical characteristics, morphologic subtypes and their
relationship to race, ethnicity and sex. Arch Dermatol 2002;
: 1567–76.
Haggstrom AN, Drolet BA, Baselga E et al. Prospective study
of infantile hemangiomas: clinical characteristics predicting
complications and treatment. Pediatrics 2006; 118: 882–7.
Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children.
N Engl J Med. 1999; 341:173-81.
Kilcline C, Frieden IJ. Infantile hemangiomas: how common
are they? A systematic review of the medical literature.
Pediatr Dermatol. 2008; 25: 168-73.
Hoornweg MJ, Smeulders MJ, van der Horst CM. Prevalence
and characteristics of haemangiomas in young children. Ned
Tijdschr Geneeskd 2005; 149: 2455–8.
Fishman SJ, Mulliken JB. Vascular anomalies: a primer for
pediatricians. Pediatr Clin North Am 1998; 45: 1455-77.
Garzon MC, Drolet BA, Baselga E, Chamlin SL, Haggstrom AN,
Horii K, et al. Hemangioma Investigator Group. Comparison
of infantile hemangiomas in preterm and term infants: a
prospective study. Arch Dermatol. 2008 Sep;144(9):1231-2.
Burton BK, Schulz CJ, Angle B, Burd L. An increased incidence
of haemangiomas in infants born following chorionic villus
sampling (CVS). Prenat Diagn 1995; 15: 209-14.
Drolet BA, Swanson EA, Frieden IJ; Hemangioma Investigator
Group. Infantile hemangiomas: an emerging health issue
linked to an increased rate of low birth weight infants. J
Pediatr. 2008; 153: 712-5.
Drolet BA, Frieden IJ. Characteristics of infantile
hemangiomas as clues to pathogenesis: does hypoxia
connect the dots? Arch Dermatol 2010;146: 1295–9.
Lopez Gutierrez JC, Avila LF, Sosa G, Patron M. Placental
anomalies in children with infantile hemangiomas. Pediatr
Dermatol 2007; 24: 353–5.
Chang EI, Thangarajah H, Hamou C, Gurtner GC. Hypoxia,
hormones, and endothelial progenitor cells in hemangioma.
Lymphat Res Biol 2007; 5: 237–43.
Boye E, Yu Y, Paranya G et al. Clonality and altered behaviour
of endothelial cells from hemangiomas. J Clin Invest 2001;
: 745–52.
Yu Y, Fuhr J, Boye E et al. Mesenchymal stem cells and
adipogenesis in hemangioma involution. Stem Cells 2006;
: 1605–12.
Ritter MR, Butschek RA, Friedlander M, Friedlander SF.
Pathogenesis of infantile haemangioma: new molecular and
cellular insights. Expert Rev Mol Med 2007; 9: 1–19.
Jinnin M, Ishihara T, Boye E, Olsen BR. Recent progress in
studies of infantile hemangioma. J Dermatol 2010; 37: 283–98.
Khan ZA, Boscolo E, Picard A et al. Multipotential stem cells
recapitulate human infantile hemangioma in immunodeficient
mice. J Clin Invest 2008; 118: 2592–9.
Yu Y, Flint AF, Mulliken JB et al. Endothelial progenitor cells
in infantile hemangiomas. Blood 2004; 103: 1373–5.
Boye E, Jinnin M, Olsen BR. Infantile hemangioma:
challenges, new insights, and therapeutic promise. J
Craniofac Surg. 2009; 20: 678-84.
Razon MJ, Kraling BM, Mulliken JB, Bischoff J. Increased
apoptosis coincides with onset of involution in infantile
hemangioma. Microcirculation 1998; 5: 189–95.
Mulliken JB, Fishman SJ, Burrows PE. Vascular anomalies.
Curr Probl Surg 2000;37:519-84.
Esterly NB. Haemangiomas. In: Harper J, Oranje A, Prose N,
eds. Textbook of pediatric dermatology. Oxford: Blackwell
Science, 2000:997-1016.
Brandling-Bennett HA, Metry DW, Baselga E et al. Infantile
hemangiomas with unusually prolonged growth phase: a
case series. Arch Dermatol 2008; 144: 1632–7.
Chang LC, Haggstrom AN, Drolet BA, Baselga E, Chamlin
SL, Garzon MC, Horii KA, Lucky AW, Mancini AJ, Metry DW,
Nopper AJ, Frieden IJ; Hemangioma Investigator Group.
Growth characteristics of infantile hemangiomas: implications
for management. Pediatrics. 2008 Aug;122: 360-7.
Garzon MC, Frieden IJ. Hemangiomas: when to worry.
Pediatric Annals 2000; 29: 58-67.
Gampper TJ, Morgan RF. Vascular anomalies: hemangiomas.
Plast Reconstr Surg 2002; 110: 572-85.
Chamlin SL, Haggstrom AN, Drolet BA, Baselga E, Frieden IJ,
Garzon MC, Horii KA, Lucky AW, Metry DW, Newell B, Nopper
AJ, Mancini AJ. Multicenter prospective study of ulcerated
hemangiomas. J Pediatr. 2007 Dec;151: 684-9, 689-1.
Yap EY, Bartley GB, Hohberger GG. Periocular capillary
hemangioma: a review for pediatricians and family
physicians. Mayo Clin Proc 1998;73: 753-9.
Metry D, Heyer G, Hess C, Garzon M, Haggstrom A,
Frommelt P, et al. PHACE Syndrome Research Conference.
Consensus Statement on diagnostic criteria for PHACE
Syndrome. Pediatrics. 2009; 124: 1447-56.
Metry DW, Garzon MC, Drolet BA, Frommelt P, Haggstrom
A, Hall J, et al. PHACE syndrome: current knowledge, future
directions. Pediatr Dermatol. 2009;26: 381-98.
Metry DW, Haggstrom AN, Drolet BA, Baselga E, Chamlin S,
Garzon M, et al. A prospective study of PHACE syndrome
in infantile hemangiomas: demographic features, clinical
findings, and complications. Am J Med Genet A. 2006:1;140:
-86.
Orlow SJ, Isakoff MS, Blei F. Increased risk of symptomatic
hemangiomas of the airway in association with cutaneous
hemangiomas in a “beard” distribution. J Pediatr 1997;131:
-6.
Girard C, Bigorre M, Guillot B, Bessis D. PELVIS syndrome.
Arch Dermatol 2006; 142: 884–8.
Stockman A, Boralevi F, Taı¨eb A, Leaute´-Labre`ze C. SACRAL
syndrome: spinal dysraphism, anogenital, cutaneous, renal
and urologic anomalies, associated with an angioma of
lumbosacral localization. Dermatology 2007; 214: 40–5.
Horii KA, Drolet BA, Frieden IJ, Baselga E, Chamlin SL,
Haggstrom AN, et al. Hemangioma Investigator Group.
Prospective study of the frequency of hepatic hemangiomas
in infants with multiple cutaneous infantile hemangiomas.
Pediatr Dermatol. 2011;28: 245-53.
Frieden IJ, Haggstrom AN, Drolet BA, Mancini AJ,
Friedlander, SF, Boon L, et al. 2005. Infantile hemangiomas:
Current knowledge, future directions. In Proceedings of a
research workshop on infantile hemangiomas;7–9, 2005,
Bethesda, Maryland. Pediatr Dermatol 22: 383–406.
C. Léauté-Labrèze,S. Prey, K. Ezzedine Infantile
haemangioma: Part II. Risks, complications and treatment.
JEADV 2011, 25, 1254–60.
Kristen E. Holland, Beth A. Drolet, Infantile Hemangioma.
Pediatr Clin N Am. 2010; 57: 1069–83.
Hasan Q, Tan ST, Gush J et al. Steroid therapy of a
proliferating hemangioma: histochemical and molecular
changes. Pediatrics 2000;105: 117-20.
Bennet ML, Fleischer AB, Chamlin SL, Frieden IJ. Oral
corticosteroid use is effective for cutaneous hemangiomas. An
evidence based evaluation. Arch Dermatol 2001;137: 1208-13.
Shorr N, Seiff SR. Central retinal artery occlusion associated
with periocular corticosteroid injection for juvenile
hemangioma. Ophtalmic Surg 1986; 17: 229–31.
Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi
F, Thambo JB, Taïeb A. Propanolol for severe hemangiomas
of infancy. N Engl J Med. 2008;358: 2649-51.
Price CJ, Lattouf C, Baum B, McLeod M, Schachner LA,
Duarte AM, Connelly EA. Propranolol vs corticosteroids for
infantile hemangiomas: a multicenter retrospective analysis.
Arch Dermatol. 2011;147(12):1371-6.
Léauté-Labrèze C, Taïeb A. Effecacité des bêtabloquants
dans les hémangiomes capillaires infantiles: signification
physiopathologique et conséquences thérapeutiques. Ann
Dermatol Venereol. 2008;135: 860-2.
Sans V, Dumas de la Roque E,Berge J, et al. Propranolol for
Severe Infantile Hemangiomas: Follow-Up Report. Pediatrics
; 124: 423.
Brain perfusion SPECT in Patients with PHACES Syndrome
under propranolol treatment Eur J Pediat Surg 2012; 22 :54-9.
Enjolras O, Breviere GM, Roger G, Tovi M,Pellegrino B,
Varotti E et al. Traitement par vincristine des hemangiomes
graves du nourrisson. Arch Pediatr 2004;11: 99-107.
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