COVID-19 e o Coração Pediátrico
DOI:
https://doi.org/10.25753/BirthGrowthMJ.v31.i3.27950Palavras-chave:
COVID-19, Long-COVID, MIS-C associado à COVID-19, Miocardite, SARS-CoV-2, Vacinas COVID-19Resumo
A doença por coronavírus entrou de rompante nas nossas vidas em 2019 com os primeiros casos reportados oriundos da cidade de Wuhan na China. A sua prevalência afetou-nos a todos, apesar das crianças apresentarem tendencialmente doença ligeira. Porém, uma nova forma de apresentação da doença, que consiste em síndrome hiperinflamatório pós COVID-19, tem emergido no grupo pediátrico, implicando maior severidade e envolvimento cardíaco. A síndrome inflamatória multissistémica em crianças (MIS-C) apresenta semelhanças importantes com outros síndromes hiperinflamatórios conhecidos, partilhando, desta forma, as suas opções terapêuticas. A terapêutica imunomodeladora tem provado reduzir o risco de complicações e severidade da doença. A vacinação pode, raramente, ter efeitos secundários graves, mas o risco-benefício abona sempre em favor da sua utilização. Apesar da escassez de dados, os sintomas a longo prazo no grupo pediátrico após infeção por COVID-19 (Covid Longa) têm sido sistematicamente descritos com impacto significativo a longo prazo na vida das crianças.
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Referências
Hoste L, Paemel R Van, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Available from: https://doi.org/10.1007/s00431-021-03993-5.
Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, et al. Characteristics and Outcomes of US Children and Adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) Compared with Severe Acute COVID-19. JAMA - J Am Med Assoc. 2021 Mar 16;325(11):1074–87.
Diniz M de FR, Cardoso MF, Sawamura KSS, Menezes CRB, Lianza AC, Pereira MFB, et al. The heart of pediatric patients with covid-19: New insights from a systematic echocardiographic study in a tertiary hospital in Brazil. Arq Bras Cardiol. 2021;117(5):954–64.
Fink TT, Marques HHS, Gualano B, Lindoso L, Bain V, Astley C, et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital. Clinics. 2021;76.
Ludvigsson JF. Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. Acta Paediatr Int J Paediatr. 2021 Mar 1;110(3):914–21.
Eberhardt CS, Siegrist CA. Is there a role for childhood vaccination against COVID-19? Vol. 32, Pediatric Allergy and Immunology. Blackwell Publishing Ltd; 2021. p. 9–16.
Bozkurt B, Kamat I, Hotez PJ. Myocarditis with COVID-19 mRNA Vaccines. Vol. 144, Circulation. Lippincott Williams and Wilkins; 2021. p. 471–84.
Niaz T, Hope K, Fremed M, Misra N, Altman C, Glickstein J, et al. Role of a Pediatric Cardiologist in the COVID-19 Pandemic. Vol. 42, Pediatric Cardiology. Springer; 2021. p. 19–35.
Jone PN, John A, Oster ME, Allen K, Tremoulet AH, Saarel EV, et al. SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association. Vol. 145, Circulation. Lippincott Williams and Wilkins; 2022. p. E1037–52.
Opoka-Winiarska V, Grywalska E, Roliński J. Pims-ts, the new pediatric systemic inflammatory disease related to previous exposure to sars-cov-2 infection—“rheumatic fever” of the 21st century? Vol. 22, International Journal of Molecular Sciences. MDPI; 2021.
Wu EY, Campbell MJ. Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Following COVID-19. Vol. 23, Current Cardiology Reports. Springer; 2021.
Stierman B, Abrams JY, Godfred-Cato SE, Oster ME, Meng L, Yip L, et al. Racial and Ethnic Disparities in Multisystem Inflammatory Syndrome in Children in the United States, March 2020 to February 2021. Pediatr Infect Dis J. 2021 Nov 1;40(11):E400–6.
Boehmer TK, Kompaniyets L, Lavery AM, et al. Association Between COVID-19 and Myocarditis Using Hospital-Based Administrative Data - United States, March 2020-January 2021. MMWR Morb Mortal Wkly Rep 2021; 70:1228.
Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, et al. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. J Pediatric Infect Dis Soc. 2021 Feb 13;10(1):34-48. doi: https://doi.org/10.1093/jpids/piaa115. PMID: 32918548; PMCID: PMC7543452.
Atkins DL, Sasson C, Hsu A, Aziz K, Becker LB, et al. 2022 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With The Guidelines-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration With the American Academy of Pediatrics, American Association for Respiratory Care, the Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists. Circ Cardiovasc Qual Outcomes. 2022 Apr;15(4):e008900. doi: https://doi.org/10.1161/CIRCOUTCOMES.122.008900. Epub 2022 Jan 24. PMID: 35072519.
Choi SH, Choi JH, Yun KW. Therapeutics for the treatment of coronavirus disease 2019 in children and adolescents. Clin Exp Pediatr. 2022 Aug;65(8):377-386. doi: https://doi.org/10.3345/cep.2022.00458. Epub 2022 Jun 27. PMID: 35760410; PMCID: PMC9348956.
Di Nardo M, Hoskote A, Thiruchelvam T, Lillie J, Horan M, Belda Hofheinz S, Dupic L, Gimeno R, de Piero ME, Lo Coco V, et al; EuroELSO Neonatal & Pediatric Working Group & collaborators on COVID-19. Extracorporeal membrane oxygenation in children with coronavirus disease 2019: preliminary report from the Collaborative European Chapter of the Extracorporeal Life Support Organization Prospective Survey. ASAIO J. 2021;67:121–124. doi: https://doi.org/10.1097/MAT.0000000000001309.
Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074–1087. doi: https://doi.org/10.1001/jama.2021.2091.
American Academy of Pediatrics. Critical Updates on COVID-19. COVID-19 interim guidance. Post-COVID-19 conditions in children and adolescents. https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/post-covid-19-conditions-in-children-and-adolescents.
Rajpal S, Tong MS, Borchers J, Zareba KM, Obarski TP, Simonetti OP, et al. Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering from COVID-19 Infection. Vol. 6, JAMA Cardiology. American Medical Association; 2021. p. 116–8.
Yasuhara J, Watanabe K, Takagi H, Sumitomo N, Kuno T. COVID-19 and multisystem inflammatory syndrome in children: a systematic review and meta-analysis. Pediatr Pulmonol. 2021;56:837–848.
Lee MS, Liu YC, Tsai CC, Hsu JH, Wu JR. Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease. Vol. 9, Frontiers in Pediatrics. Frontiers Media S.A.; 2021.
Matsubara D, Kauffman HL, Wang Y, et al. Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States.J Am Coll Cardiol. 2020;76(17): 1947-1961. doi: https://doi.org/10.1016/j.jacc.2020.08.056.
Buonsenso D, Riitano F, Valentini P. Pediatric Inflammatory Multisystem Syndrome Temporally Related With SARS-CoV-2: Immunological Similarities With Acute Rheumatic Fever and Toxic Shock Syndrome. Vol. 8, Frontiers in Pediatrics. Frontiers Media S.A.; 2020.
Gewitz MH, Baltimore RS, Tani LY, Sable CA, Shulman ST, Carapetis J, et al. Revision of the Jones criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography a scientific statement from the American heart association. Circulation. 2015;131(20):1806–18.
Kim RJ, Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, et al. Patients with acute myocarditis following mrna covid-19 vaccination. JAMA Cardiol. 2021 Oct 1;6(10):1196–201.
Buonsenso D, Munblit D, De Rose C, Sinatti D, Ricchiuto A, Carfi A, et al. Preliminary evidence on long COVID in children. Acta Paediatr Int J Paediatr. 2021 Jul 1;110(7):2208–11.
Ashkenazi-Hoffnung L, Shmueli E, Ehrlich S, Ziv A, Bar-On O, Birk E, et al. Long COVID in Children: Observations from a Designated Pediatric Clinic. Pediatr Infect Dis J. 2021 Dec 1;40(12):E509–11.
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