Dermatology case


  • Sandrina Carvalho Department of Dermatology, Centro Hospitalar do Porto
  • Susana Vilaça Department of Dermatology, Centro Hospitalar do Porto
  • Manuela Selores Department of Dermatology, Centro Hospitalar do Porto



Fox-Fordyce disease, skin rash, apocrine glands


The Fox-Fordyce disease represents an infrequent chronic pruritic skin rash of unknown etiology caused by obstruction of apocrine glands. Clinically it is characterized by multiple skin color and / or erythematous perifollicular papules in areas rich of apocrine glands (armpits, genital area, areolas and infra-mammary fold). Retinoids, antibiotics and topical immunomodulators have been used with varying results. We describe a case of a 16-yearold girl with Fox-Fordyce disease.


Download data is not yet available.


Fox G, Fordyce J. Two cases of a rare papular disease affecting

the axillary region. J Cutan Genito -Urinary Dis 1902;

:1 -5.

Feldmann R, Masouy I, Chavaz P, Saurat JH. Fox -Fordyce

disease. Dermatology 1992;184: 310 -13.

Kamada A, Saga K, Jimbow K. Apoeccrine sweat duct obstruction

as a cause for Fox -Fordyce disease. J Am Acad Dermatol

; 48: 453 -5.

Ber A. Patterns histopathologic of Fox -Fordyce disease. Am J

Dermatopathol 2004; 26: 482 -92.

Ghislain PD, van Der Endt JD, Delescluse J. Itchy papules of

the axillae. Arch Dermatol 2002;138: 259 -64.

Effendy I, Ossowski B, Happle R. Fox- Fordyce disease in a

male patient - -response to oral retinoid treatment. Clin Exp

Dermatol 1994;19: 67 -9.

Miller ML, Harford RR, Yeager JK. Fox -Fordyce disease treated

with topical clindamycin solution. Arch Dermatol 1995;

:1112 -3.

Pock L, Svrckova M, Machackova R, Hercogova J. Pimecrolimus

is effective in Fox -Fordyce disease. Int J Dermatol 2006;

:1134 -5.



How to Cite

Carvalho S, Vilaça S, Selores M. Dermatology case. REVNEC [Internet]. 2017Aug.22 [cited 2024May29];22(1):42-3. Available from:



Imaging Cases

Most read articles by the same author(s)

1 2 > >>